Gold nanocages (AuNCs) have been shown to be a useful tool both for imaging and hyperthermia therapy of cancer, thanks to their outstanding optical properties, low toxicity and facile functionalization with targeting molecules, including peptides and antibodies. In particular, hyperthermia is a minimally invasive therapy which takes advantage of the peculiar properties of gold nanoparticles to efficiently convert the absorbed light into heat. Here, we use AuNCs for the selective targeting and imaging of prostate cancer cells. Moreover, we report the hyperthermic effect characterization of the AuNCs both in solution and internalized in cells. Prostate cancer cells were irradiated at different exposure times, with a pulsed near infrared laser, and the cellular viability was evaluated by confocal microscopy.
Gold nanocages for imaging and therapy of prostate cancer cells / L. Sironi, S. Avvakumova, E. Galbiati, S.A. Locarno, C. Macchi, L. D'Alfonso, M. Ruscica, P. Magni, M. Collini, S. Romeo, G. Chirico, D. Prosperi - In: Biophotonics: photonic solutions for better health care / [a cura di] J. Popp, V.V. Tuchin, D.L. Matthews, F.S. Pavone. - [s.l] : SPIE, 2016 Apr. - ISBN 9781510601321. - pp. 1-1 (( Intervento presentato al 5. convegno Biophotonics: Photonic Solutions for Better Health Care tenutosi a Bruxelles nel 2016.
Titolo: | Gold nanocages for imaging and therapy of prostate cancer cells |
Autori: | |
Parole Chiave: | Gold; Prostate cancer; Toxicity; Cancer; Confocal microscopy; Lasers; Molecules; Nanoparticles; Near infrared; Optical properties |
Settore Scientifico Disciplinare: | Settore MED/04 - Patologia Generale Settore MED/05 - Patologia Clinica Settore CHIM/08 - Chimica Farmaceutica |
Data di pubblicazione: | apr-2016 |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1117/12.2229715 |
Tipologia: | Book Part (author) |
Appare nelle tipologie: | 03 - Contributo in volume |
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Gold nanocages for imaging and therapy of prostate cancer cells.pdf | Post-print, accepted manuscript ecc. (versione accettata dall'editore) | Open Access Visualizza/Apri |