Mucosa of the buccal cavity is considered a convenient and easily accessible site for the administration of drugs intended for both local and systemic delivery. Aiming to optimize the pharmacokinetic, buccal mucoadhesive drug delivery systems are proposed. Mucoadhesion is a complex process involving chemical interactions between mucin and polymers. The success and degree of mucoadhesion bonding is based on various polymer-based features. The evolution of such systems has moved from first-generation hydrophilic polymers, able to form unspecific interactions, to more specific second-generation systems based on lectins, or on novel materials obtained by modification of polymers with various functional groups such as thiol groups. A wide range of formulations has been proposed for the delivery of small molecules, but comparatively few have found their way onto the market. The article reviews the information regarding the most promising mucoadhesive polymers and their application in the design and development of buccal mucoadhesive dosage forms.

A focus on mucoadhesive polymers and their application in buccal dosage forms / E. Russo, F. Selmin, S. Baldassari, C.G.M. Gennari, G. Caviglioli, F. Cilurzo, P. Minghetti, B. Parodi. - In: JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY. - ISSN 1773-2247. - 32(2016 Apr), pp. 113-125. [10.1016/j.jddst.2015.06.016]

A focus on mucoadhesive polymers and their application in buccal dosage forms

F. Selmin
Secondo
;
C.G.M. Gennari;F. Cilurzo;P. Minghetti
Penultimo
;
2016

Abstract

Mucosa of the buccal cavity is considered a convenient and easily accessible site for the administration of drugs intended for both local and systemic delivery. Aiming to optimize the pharmacokinetic, buccal mucoadhesive drug delivery systems are proposed. Mucoadhesion is a complex process involving chemical interactions between mucin and polymers. The success and degree of mucoadhesion bonding is based on various polymer-based features. The evolution of such systems has moved from first-generation hydrophilic polymers, able to form unspecific interactions, to more specific second-generation systems based on lectins, or on novel materials obtained by modification of polymers with various functional groups such as thiol groups. A wide range of formulations has been proposed for the delivery of small molecules, but comparatively few have found their way onto the market. The article reviews the information regarding the most promising mucoadhesive polymers and their application in the design and development of buccal mucoadhesive dosage forms.
Mucoadhesion; Buccal mucosa; Buccal drug delivery; Mucoadhesive polymers; Sustained release; Fast-dissolving
Settore CHIM/09 - Farmaceutico Tecnologico Applicativo
apr-2016
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/378453
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