Background: The diagnosis of vasovagal syncope continues to be difficult despite the use of accurate histories, tilt testing and implantable loop recorders. A circulating biomarker might be useful to facilitate diagnoses. Both endothelin-1 and vasopressin are increased during positive tilt tests resulting in syncope. Copeptin is a stable cleavage product of vasopressin formation. We conducted a pilot study to assess the utility of endothelin-1 and copeptin as circulating biomarkers of vasovagal syncope. Methods: Three populations were studied: syncope patients, epilepsy patients and controls. Vasovagal syncope diagnosis was ascertained with the Calgary Syncope Score and epilepsy diagnosis was confirmed with EEG. Plasma levels of endothelin-1 were measured using by ELISA and copeptin levels were determined using an EIA kit. Results: Asymptomatic control subjects had mean age 35 ± 11 years (7/22 male); epileptic subjects had mean age 32 ± 7 years (4/15 male); and syncope subjects had mean age 33 ± 16 years (4 of 21 male). Circulating plasma levels of endothelin-1 and copeptin were no different among the three groups. Mean concentrations of endothelin-1 were as follows: syncope, 23 ± 32 pg/mL; controls, 21 ± 17 pg/mL; and epileptics, 18 ± 12 pg/mL. Mean concentrations of copeptin were as follows: syncope, 1·29 ± 0·79 ng/mL; controls, 1·25 ± 0·79 ng/mL; and seizures, 1·23 ± 0·45 ng/mL. There were no significant correlations between syncope frequency and copeptin or endothelin-1 levels. Conclusion: Circulating plasma endothelin-1 and copeptin levels are not significantly different among populations of controls, syncope patients and seizure patients.
Assessment of endothelin and copeptin as biomarkers for vasovagal syncope / A. Rash, M. Mcrae, J. Fatehi, D. Richie, M. Solbiati, N. Pillay, A. Ulke-Lemée, J. Macdonald, R. Sheldon. - In: EUROPEAN JOURNAL OF CLINICAL INVESTIGATION. - ISSN 0014-2972. - 46:2(2016 Feb), pp. 141-145.
|Titolo:||Assessment of endothelin and copeptin as biomarkers for vasovagal syncope|
|Parole Chiave:||biomarkers; copeptin; diagnosis; endothelin; vasovagal syncope|
|Settore Scientifico Disciplinare:||Settore MED/09 - Medicina Interna|
|Data di pubblicazione:||feb-2016|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1111/eci.12576|
|Appare nelle tipologie:||01 - Articolo su periodico|
File in questo prodotto:
|Rash_et_al-2016-European_Journal_of_Clinical_Investigation.pdf||Publisher's version/PDF||Administrator Richiedi una copia|