Trigeminal hyperalgesia frequently appears in diabetic neuralgia altering the transmission of orofacial sensory information. This study was designed to explore the effects of trigeminal hyperalgesia in streptozotocin-induced diabetes monitoring the expression of nitric oxide synthase in the trigeminal ganglion cells. The threshold to heat noxious stimuli decreased in diabetic animals. The number of NADPH-diaphorase (NADPH-d)-positive neurons significantly decreased in the diabetic rats compared with controls. Insulin treatment prevented the decreased nociceptive threshold and reduction of the number of NADPH-d-positive neurons. These findings point out that there is a relationship between the trigeminal nociceptive perception and NADPH-d neuronal expression suggesting that NO may play a role in the pathogenesis of trigeminal sensory neuropathy.
|Titolo:||Nitric oxide involvement in the trigeminal hyperalgesia in diabetic rats|
BIANCHI, ROSSELLA (Ultimo)
|Data di pubblicazione:||19-mag-2000|
|Digital Object Identifier (DOI):||10.1016/S0006-8993(00)02235-6|
|Appare nelle tipologie:||01 - Articolo su periodico|