The Pd-catalyzed alkynylation of various alkenyl halides and triflates with alkynylzincs proceeds well even with alkynyl derivatives containing electron-withdrawing groups. The reaction appears to be highly general. Noteworthy is that the corresponding Sonogashira reactions under various reported conditions are significantly less satisfactory in all cases performed in this study.
|Titolo:||Highly satisfactory alkynylation of alkenyl halides via Pd-catalyzed cross-coupling with alkynylzincs and its critical comparison with the Sonogashira alkynylation|
ANASTASIA, LUIGI (Penultimo)
|Parole Chiave:||Carbon bond formation; conjugated diynes; diastereoselective synthesis; multidrug-resistance; general-synthesis; convenient route; aryl halides; palladium; efficient; organozincs|
|Settore Scientifico Disciplinare:||Settore BIO/10 - Biochimica|
|Data di pubblicazione:||15-mag-2003|
|Digital Object Identifier (DOI):||10.1021/ol030010F|
|Appare nelle tipologie:||01 - Articolo su periodico|