Antibiotic therapy represents an essential aid in the treatment of sick or injured loggerhead sea turtle (Caretta caretta,). Marbofloxacin is commonly used in loggerhead sea turtles at 2 mgjkg similarly to other species. The aim of the study was to increase our understanding of marbofloxacin pharmacokinetic in Caretta caretta. Six healthy turtles were divided in two groups: the IV group (subjects A, B, D) and the IM group (subjects C, H, F). Each animal received a single dose of MarbocyP 2%, corresponding to 2 mg/ kg of marbofloxacin. The drug was administered via intravenous (IV) and intramuscular (IM) routes. After the administration, 13 blood samples were collected at different times:for IVgroup at 0, 10, 20, 30, 45 minutes, 1, 2, 4, 8, 12 hours and 1, 2, 2,5 days; for IM group at 0, 30 minutes, 1, 1.5, 2, 3, 4, 6, 8, 12 hours, and 1, 2, 2,5 days. A HPLC-UV (k 295 nm) analytical method was used to measure marbofloxacin concentrations in blood. The pharmacokinetic behavior of the drug was best described by a non-compartmental model The plasma concentration profiles of marbofloxacin were similar for the two administration routes and the residual concentrations at 1 day were almost identical. The molecule was detected up to 2,5 days. The apparent volume of distribution was > 1 L/kg. The IM route resulted in a rapid and complete marbofloxacin absorption (F = 131, 43 ±12,06%).

Nuovi dati sperimentali sul profilo cinetico di marbofloxacina nella tartaruga comune (Caretta caretta) dopo somministrazione endovenosa e intramuscolare = Update on pharmacokinetic profile of marbofloxacin in loggerhead sea turtles (Caretta caretta) after intravenous and intramuscular injection / G. Nardini, F. Maffucci, N. Di Girolamo, F. Bentivegna, A. Barbarossa, P. Cagnardi, S. Leopardi, A. Zaghini. - In: VETERINARIA. - ISSN 0394-3151. - 29:5(2015), pp. 53-58.

Nuovi dati sperimentali sul profilo cinetico di marbofloxacina nella tartaruga comune (Caretta caretta) dopo somministrazione endovenosa e intramuscolare = Update on pharmacokinetic profile of marbofloxacin in loggerhead sea turtles (Caretta caretta) after intravenous and intramuscular injection

P. Cagnardi;
2015

Abstract

Antibiotic therapy represents an essential aid in the treatment of sick or injured loggerhead sea turtle (Caretta caretta,). Marbofloxacin is commonly used in loggerhead sea turtles at 2 mgjkg similarly to other species. The aim of the study was to increase our understanding of marbofloxacin pharmacokinetic in Caretta caretta. Six healthy turtles were divided in two groups: the IV group (subjects A, B, D) and the IM group (subjects C, H, F). Each animal received a single dose of MarbocyP 2%, corresponding to 2 mg/ kg of marbofloxacin. The drug was administered via intravenous (IV) and intramuscular (IM) routes. After the administration, 13 blood samples were collected at different times:for IVgroup at 0, 10, 20, 30, 45 minutes, 1, 2, 4, 8, 12 hours and 1, 2, 2,5 days; for IM group at 0, 30 minutes, 1, 1.5, 2, 3, 4, 6, 8, 12 hours, and 1, 2, 2,5 days. A HPLC-UV (k 295 nm) analytical method was used to measure marbofloxacin concentrations in blood. The pharmacokinetic behavior of the drug was best described by a non-compartmental model The plasma concentration profiles of marbofloxacin were similar for the two administration routes and the residual concentrations at 1 day were almost identical. The molecule was detected up to 2,5 days. The apparent volume of distribution was > 1 L/kg. The IM route resulted in a rapid and complete marbofloxacin absorption (F = 131, 43 ±12,06%).
Veterinary (all)
Settore VET/07 - Farmacologia e Tossicologia Veterinaria
2015
http://www.scivac.it
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/375329
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