Production of chemokines by intestinal epithelial cells is a key step in the amplification of the destructive immune-inflammatory response in patients with inflammatory bowel diseases [IBD]. In this study, we examined whether intestinal epithelial cells express macrophage colony-stimulating factor receptor 1 [M-CSFR-1], the functional receptor of interleukin-34 [IL-34], a cytokine that is over-produced in IBD and supposed to sustain inflammatory pathways.
Interleukin-34 Induces Cc-chemokine Ligand 20 in Gut Epithelial Cells / E. Franzè, I. Marafini, V. De Simone, I. Monteleone, F. Caprioli, A. Colantoni, A. Ortenzi, F. Crescenzi, R. Izzo, G. Sica, P. Sileri, P. Rossi, F. Pallone, G. Monteleone. - In: JOURNAL OF CROHN'S AND COLITIS. - ISSN 1873-9946. - 10:1(2016 Jan), pp. 87-94.
Interleukin-34 Induces Cc-chemokine Ligand 20 in Gut Epithelial Cells
F. Caprioli;
2016
Abstract
Production of chemokines by intestinal epithelial cells is a key step in the amplification of the destructive immune-inflammatory response in patients with inflammatory bowel diseases [IBD]. In this study, we examined whether intestinal epithelial cells express macrophage colony-stimulating factor receptor 1 [M-CSFR-1], the functional receptor of interleukin-34 [IL-34], a cytokine that is over-produced in IBD and supposed to sustain inflammatory pathways.
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