Abstract Increasing evidence underlines that prototypical inflammatory cytokines (IL-1β, TNF-α and IL-6) either synthesized in the central (CNS) or peripheral nervous system (PNS) by resident cells, or imported by immune blood cells, are involved in several pathophysiological functions, including an unexpected impact on synaptic transmission and neuronal excitability. This review describes these unconventional neuromodulatory properties of cytokines, that are distinct from their classical action as effector molecules of the immune system. In addition to the role of cytokines in brain physiology, we report evidence that dysregulation of their biosynthesis and cellular release, or alterations in receptor-mediated intracellular pathways in target cells, leads to neuronal cell dysfunction and modifications in neuronal network excitability. As a consequence, targeting of these cytokines, and related signalling molecules, is considered a novel option for the development of therapies in various CNS or PNS disorders associated with an inflammatory component. This article is part of a Special Issue entitled 'Neuroimmunology and Synaptic Function'.

Neuromodulatory properties of inflammatory cytokines and their impact on neuronal excitability / A. Vezzani, B. Viviani. - In: NEUROPHARMACOLOGY. - ISSN 0028-3908. - 96:pt A(2015), pp. 70-82. [10.1016/j.neuropharm.2014.10.027]

Neuromodulatory properties of inflammatory cytokines and their impact on neuronal excitability

B. Viviani
Ultimo
2015

Abstract

Abstract Increasing evidence underlines that prototypical inflammatory cytokines (IL-1β, TNF-α and IL-6) either synthesized in the central (CNS) or peripheral nervous system (PNS) by resident cells, or imported by immune blood cells, are involved in several pathophysiological functions, including an unexpected impact on synaptic transmission and neuronal excitability. This review describes these unconventional neuromodulatory properties of cytokines, that are distinct from their classical action as effector molecules of the immune system. In addition to the role of cytokines in brain physiology, we report evidence that dysregulation of their biosynthesis and cellular release, or alterations in receptor-mediated intracellular pathways in target cells, leads to neuronal cell dysfunction and modifications in neuronal network excitability. As a consequence, targeting of these cytokines, and related signalling molecules, is considered a novel option for the development of therapies in various CNS or PNS disorders associated with an inflammatory component. This article is part of a Special Issue entitled 'Neuroimmunology and Synaptic Function'.
Blood-brain barrier; Channelopathy; Cognition; Epilepsy; Glia; Glutamate and GABA receptors; Innate immunity; Neuroinflammation; Neuropathology; Synaptic transmission; Animals; Calcium Channels; Cytokines; Humans; Inflammation Mediators; Interleukin-1beta; Interleukin-6; Neuroglia; Neuronal Plasticity; Neurons; Potassium Channels, Voltage-Gated; Signal Transduction; Tumor Necrosis Factor-alpha; Voltage-Gated Sodium Channels; Synaptic Transmission; Cellular and Molecular Neuroscience; Pharmacology
Settore BIO/14 - Farmacologia
8-nov-2014
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/374439
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