Asenapine is a second-generation antipsychotic with a unique pharmacological profile that was recently approved for the treatment of moderate/severe manic episodes. Real-world data on rapidity of action in inpatient settings are lacking. The aims of the current real-world observational study were to evaluate: (i) short-term efficacy of asenapine after 7 days (T0-T1) in patients hospitalized for a manic episode in the course of bipolar I disorder or schizoaffective disorder (group A), (ii) differences in length of stay (LoS), and (iii) rehospitalization compared to a control population (group B) with a 6-month follow-up. Twenty patients were included in each group. The mean total Young Mania Rating Scale score decreased by 12.6 (SD ±10.3; t(17) = 5.2, P < 0.005), implying a mean 37.8% improvement. A statistically significant reduction was observed for all Young Mania Rating Scale items, except for “sexual interest.” The mean total BPRS score decreased by 17.2 (SD ±14.9; t(17) = 4.9, P < 0.005). A statistically significant reduction was observed for several items, including “conceptual disorganization,” “grandiosity,” “unusual thought content,” and “excitement”. Length of stay was 17.9 (SD ±9.0) days for group A and 14.7 (SD ±12.7) days for group B; the result of the Kruskal-Wallis test showed no significant differences (χ2 = 2.199, P = 0.138). Despite a high discontinuation rate, only 17.7% of patients in group Awere rehospitalized in the following 6 months compared to 41.2% of those in group B (relative risk = 0.43, 95% confidence interval, 0.13–1.39). Findings from this small, preliminary study at least partially support the results of previous trials, confirming effectiveness and tolerability in the context of comorbidity and polypsychopharmacology.
Asenapine in the Treatment od Acute Mania : a Real-World Observational Study with 6 Months Follow-up / E.G. Ostinelli, S. Cavallotti, A. Castelnovo, E. Guanella, O. Gambini, A. D'Agostino. - In: JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY. - ISSN 0271-0749. - 35:5(2015 Oct), pp. 553-558.
|Titolo:||Asenapine in the Treatment od Acute Mania : a Real-World Observational Study with 6 Months Follow-up|
CAVALLOTTI, SIMONE (Secondo)
|Parole Chiave:||mood disorder; affective psychosis; manic episode; second-generation antipsychotics|
|Settore Scientifico Disciplinare:||Settore MED/25 - Psichiatria|
|Data di pubblicazione:||ott-2015|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1097/JCP.0000000000000374|
|Appare nelle tipologie:||01 - Articolo su periodico|