Complex sphingolipids are essential structural components of intestinal membranes, providing protection and integrity to the intestinal mucosa and regulating intestinal absorption processes. The role of sphingolipid signaling has been established in numerous cellular events, including intestinal cell survival, growth, differentiation, and apoptosis. A significant body of knowledge demonstrates that intestinal sphingolipids play a crucial role, as such and through their signaling pathways, in immunity and inflammatory disorders. In this review, we report on and discuss the current knowledge on the metabolism, signaling, and functional implications of sphingolipids in inflammatory bowel disease (IBD), focusing on the different aspects of sphingolipid actions on inflammatory responses and on the potential of sphingolipid-targeted molecules as anti-IBD therapeutic agents.

Fostering inflammatory bowel disease: sphingolipid strategies to join forces / L. Abdel Hadi, C. Di Vito, L. Riboni. - In: MEDIATORS OF INFLAMMATION. - ISSN 1466-1861. - (2016), pp. 3827684.1-3827684.13.

Fostering inflammatory bowel disease: sphingolipid strategies to join forces

L. Abdel Hadi
Primo
;
C. Di Vito
Secondo
;
L. Riboni
Ultimo
2016

Abstract

Complex sphingolipids are essential structural components of intestinal membranes, providing protection and integrity to the intestinal mucosa and regulating intestinal absorption processes. The role of sphingolipid signaling has been established in numerous cellular events, including intestinal cell survival, growth, differentiation, and apoptosis. A significant body of knowledge demonstrates that intestinal sphingolipids play a crucial role, as such and through their signaling pathways, in immunity and inflammatory disorders. In this review, we report on and discuss the current knowledge on the metabolism, signaling, and functional implications of sphingolipids in inflammatory bowel disease (IBD), focusing on the different aspects of sphingolipid actions on inflammatory responses and on the potential of sphingolipid-targeted molecules as anti-IBD therapeutic agents.
intestinal epithelial-cells; sodium-induced colitis; necrosis-factor-alpha; gene-deficient mice; mucosal alkaline sphingomyelinase; cytosolic phospholipase A(2); arachidonic-acid release; ulcerative-colitis; sphingosine kinase; barrier function
Settore BIO/10 - Biochimica
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/373573
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