A solvent-free microwave-assisted methodology for the obtainment of the hydroxyethylamine (HEA) isostere is described. A phenylalanine derived aminoalkyl epoxide is allowed to react with a dipeptide amine using basic alumina partially deactivated with water under microwave irradiation. The HEA is obtained in very short time (3 min). This methodology is amenable to application in a parallel or automatic sequential format. Copyright
Amino acid derived epoxide ring opening tinder microwave irradiation / N. Vaiana, L. Rizzi, S. Romeo. - In: CHEMISTRY LETTERS. - ISSN 0366-7022. - 36:5(2007 May 05), pp. 648-649. [10.1246/cl.2007.648]
Amino acid derived epoxide ring opening tinder microwave irradiation
N. VaianaPrimo
;L. RizziSecondo
;S. RomeoUltimo
2007
Abstract
A solvent-free microwave-assisted methodology for the obtainment of the hydroxyethylamine (HEA) isostere is described. A phenylalanine derived aminoalkyl epoxide is allowed to react with a dipeptide amine using basic alumina partially deactivated with water under microwave irradiation. The HEA is obtained in very short time (3 min). This methodology is amenable to application in a parallel or automatic sequential format. Copyright
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