A solvent-free microwave-assisted methodology for the obtainment of the hydroxyethylamine (HEA) isostere is described. A phenylalanine derived aminoalkyl epoxide is allowed to react with a dipeptide amine using basic alumina partially deactivated with water under microwave irradiation. The HEA is obtained in very short time (3 min). This methodology is amenable to application in a parallel or automatic sequential format. Copyright

Amino acid derived epoxide ring opening tinder microwave irradiation / N. Vaiana, L. Rizzi, S. Romeo. - In: CHEMISTRY LETTERS. - ISSN 0366-7022. - 36:5(2007 May 05), pp. 648-649.

Amino acid derived epoxide ring opening tinder microwave irradiation

N. Vaiana
Primo
;
L. Rizzi
Secondo
;
S. Romeo
Ultimo
2007-05-05

Abstract

A solvent-free microwave-assisted methodology for the obtainment of the hydroxyethylamine (HEA) isostere is described. A phenylalanine derived aminoalkyl epoxide is allowed to react with a dipeptide amine using basic alumina partially deactivated with water under microwave irradiation. The HEA is obtained in very short time (3 min). This methodology is amenable to application in a parallel or automatic sequential format. Copyright
Settore CHIM/08 - Chimica Farmaceutica
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/37197
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