We studied quantitative changes in mitochondria of perineuronal satellite cell sheaths (SCSs) of rabbit spinal ganglia from young to extremely advanced age (1, 3.6, 6.7 and 8.8 years). The mitochondrial structure did not differ in the four age groups, while mitochondrial size increased progressively and significantly with age. The mean percentage of cytoplasmic volume occupied by mitochondria decreased progressively and significantly from young to old animals. This decrease was mainly due to a progressive and significant reduction in the total mitochondrial volume. Lipofuscin accumulation had a negligible influence on this reduction. These results suggest that the ability of SCSs to produce energy decreases with age and that the reduced ability of spinal ganglion neurons to respond to high energy demands in old age may be in part due to the diminished contribution of perineuronal satellite cells.
Mitochondria in perineuronal satellite cell sheaths of rabbit spinal ganglia : quantitative changes during life / C. Martinelli, P. Sartori, M. Ledda, E. Pannese. - In: CELLS TISSUES ORGANS. - ISSN 1422-6405. - 186:2(2007), pp. 141-146.
|Titolo:||Mitochondria in perineuronal satellite cell sheaths of rabbit spinal ganglia : quantitative changes during life|
MARTINELLI, CARLA (Primo)
SARTORI, PATRIZIA (Secondo)
LEDDA, MARIA (Penultimo)
PANNESE, ENNIO (Ultimo)
|Parole Chiave:||Aging; Dorsal root ganglia; Perineuronal satellite cells; Peripheral neuroglia; Sensory ganglia|
|Settore Scientifico Disciplinare:||Settore BIO/17 - Istologia|
|Data di pubblicazione:||2007|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1159/000104408|
|Appare nelle tipologie:||01 - Articolo su periodico|
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