Objective: The Italian Society for Pediatric Infectious Diseases created a registry on children with infective endocarditis (IE) hospitalized in Italy.Methods: A cross-sectional survey was conducted on patients hospitalized due to IE in Italian paediatric wards between January 1, 2000, and June 30, 2015.Results: Over the 15-year study period, 47 IE episodes were observed (19 males; age range, 2-17 years). Viridans Streptococci were the most common pathogens among patients with predisposing cardiac conditions and Staphylococcus aureus among those without (37.9% vs. 5.5%, p = 0.018, and 6.9% vs. 27.8%, p = 0.089, respectively). Six of the 7 (85.7%) S. aureus strains were methicillin-resistant. The majority of patients with and without predisposing cardiac conditions recovered without any complications.Conclusion: In Italy, paediatric IE develops without any previous predisposing factors in a number of children, methicillin-resistant S. aureus has emerged as a common causative agent and the therapeutic approach is extremely variable.
Infective Endocarditis in Children in Italy from 2000 to 2015 / S. Esposito, A. Mayer, A. Krzysztofiak, S. Garazzino, R. Lipreri, L. Galli, P. Osimani, E. Fossali, M. Di Gangi, L. Lancella, M. Denina, G. Pattarino, C. Montagnani, F. Salvini, A. Villani, N. Principi. - In: EXPERT REVIEW OF ANTI-INFECTIVE THERAPY. - ISSN 1478-7210. - 14:3(2016 Mar), pp. 353-358.
|Titolo:||Infective Endocarditis in Children in Italy from 2000 to 2015|
ESPOSITO, SUSANNA (Corresponding)
MAYER, ALESSANDRA (Secondo)
PRINCIPI, NICOLA (Ultimo)
|Parole Chiave:||anti-infective therapy; antibiotics; congenital heart disease; infective endocarditis; Staphylococcus aureus; viridans Streptococci; infectious diseases; microbiology (medical); microbiology; virology|
|Settore Scientifico Disciplinare:||Settore MED/38 - Pediatria Generale e Specialistica|
|Data di pubblicazione:||mar-2016|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1586/14787210.2016.1136787|
|Appare nelle tipologie:||01 - Articolo su periodico|