In peripheral neuropathies, such as sensorimotor neuropathies, motor neuron diseases, or the Guillain-Barré syndrome, serum antibodies recognizing saccharide units, portion of oligosaccharides, or oligosaccharide chains, have been found. These antibodies are called anti-glycosphingolipid (GSL) or anti-ganglioside antibodies.However, the information on the aglycone carrying the hydrophilic oligosaccharide remains elusive. The absolute and unique association of GSL to the onset, development and symptomatology of the peripheral neuropathies could be misleading. Here, we report some thoughts on the matter.
Serum antibodies to glycans in peripheral neuropathies / S. Sonnino, E. Chiricozzi, M.G. Ciampa, L. Mauri, A. Prinetti, G. Toffano, M. Aureli. - In: MOLECULAR NEUROBIOLOGY. - ISSN 0893-7648. - 54:2(2017 Mar), pp. 1564-1567. [10.1007/s12035-016-9775-8]
Serum antibodies to glycans in peripheral neuropathies
S. Sonnino;E. Chiricozzi;M.G. Ciampa;L. Mauri;A. Prinetti;M. Aureli
2017
Abstract
In peripheral neuropathies, such as sensorimotor neuropathies, motor neuron diseases, or the Guillain-Barré syndrome, serum antibodies recognizing saccharide units, portion of oligosaccharides, or oligosaccharide chains, have been found. These antibodies are called anti-glycosphingolipid (GSL) or anti-ganglioside antibodies.However, the information on the aglycone carrying the hydrophilic oligosaccharide remains elusive. The absolute and unique association of GSL to the onset, development and symptomatology of the peripheral neuropathies could be misleading. Here, we report some thoughts on the matter.File | Dimensione | Formato | |
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