A possible relationship between gluten sensitivity (GS) and Meniere’s Disease (MD) has already been reported in literature. Many authors are currently studying the humoral immune responses (biomarkers) to all wheat antigens and peptides in patients with diseases that are related to wheat ingestion. The aim of this study was to assess the humoral immune responses to wheat antigens, and in particular, IgG and IgA antibody production against all of the antigens and peptides associated with gliadin in patients with MD with or without GS (MD-GS+ and MD-GS-). We used the sera of 28 patients with MD, 14 of whom proved to be sensitive to gliadin at skin prick testing and 14 whose results were negative. The serum of 100 healthy patients was used as the control in order to establish the normal range for the biomarkers tested. There were no signi cant differences between MD-GS+ and MD-GS- for all of the biomarkers with the exception of IgG anti-transglutaminase 3. (p < 0.005) Our results con rm the importance of the delayed response to skin prick testing in identifying patients with GS in MD, as previously reported in literature. The increase of IgG anti Transglutaminase 3 antibodies requires further study in order to de ne whether it is purely incidental.
Gluten sensitivity and Meniere's disease / F. Di Berardino, D. Soi, D. Alpini, E. Filipponi, A. Cesarani - In: Meniere's Disease and Inner Ear Disorders : abstract bookPrima edizione. - [s.l] : Pacini, 2015. - pp. 72-72 (( Intervento presentato al 7. convegno Meniere's Disease and Inner Ear Disorders tenutosi a Roma nel 2015.
|Titolo:||Gluten sensitivity and Meniere's disease|
DI BERARDINO, FEDERICA (Primo)
FILIPPONI, ELIANA (Penultimo)
CESARANI, ANTONIO (Ultimo)
|Settore Scientifico Disciplinare:||Settore MED/32 - Audiologia|
|Data di pubblicazione:||2015|
|Tipologia:||Book Part (author)|
|Appare nelle tipologie:||03 - Contributo in volume|