BACKGROUND: CCL28 (MEC) binds to CCR3 and CCR10 and recruits IgA-secreting plasma cells (IgA-ASC) in the mucosal lamina propria (MLP). Mucosal HIV-specific IgA are detected in HIV-infection and exposure. The CCL28 circuit was analyzed in HIV-infected and-exposed individuals and in HIV-unexposed controls; the effect of CCL28 administration on gastrointestinal MLP IgA-ASC was verified in a mouse model. METHODOLOGY/FINDINGS: CCL28 was augmented in breast milk (BM) plasma and saliva of HIV-infected and -exposed individuals; CCR3+ and CCR10+ B lymphocytes were increased in these same individuals. Additionally: 1) CCL28 concentration in BM was associated with longer survival in HIV vertically-infected children; and 2) gastro-intestinal mucosal IgA-ASC were significantly increased in VSV-immunized mice receiving CCL28. CONCLUSIONS: CCL28 mediates mucosal immunity in HIV exposure and infection. CCL28-including constructs should be considered in mucosal vaccines to prevent HIV infection of the gastro-intestinal MLP via modulation of IgA-ASC.
The mucosae-associated epithelial chemokine (MEC/CCL28) modulates immunity in HIV infection / E. Castelletti, S. Lo Caputo, L. Kuhn, M. Borelli, J. Gajardo, M. Sinkala, D.L. Trabattoni, C. Kankasa, E. Lauri, A. Clivio, L. Piacentini, D.H. Bray, G.M. Aldrovandi, D.M. Thea, F. Veas, M. Nebuloni, F. Mazzotta, M.S. Clerici. - In: PLOS ONE. - ISSN 1932-6203. - 2:10 (e969)(2007).
|Titolo:||The mucosae-associated epithelial chemokine (MEC/CCL28) modulates immunity in HIV infection|
CASTELLETTI, ELEONORA (Primo)
CLERICI, MARIO SALVATORE (Ultimo)
|Settore Scientifico Disciplinare:||Settore MED/04 - Patologia Generale|
Settore MED/08 - Anatomia Patologica
Settore BIO/13 - Biologia Applicata
|Data di pubblicazione:||2007|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1371/journal.pone.0000969|
|Appare nelle tipologie:||01 - Articolo su periodico|