A successful approach for predicting functional associations between non-homologous genes is to compare their phylogenetic distributions. We have devised a phylogenetic profiling algorithm, SVD-Phy, which uses truncated singular value decomposition to address the problem of uninformative profiles giving rise to false positive predictions. Benchmarking the algorithm against the KEGG pathway database, we found that it has substantially improved performance over existing phylogenetic profiling methods.
SVD-phy : improved prediction of protein functional associations through singular value decomposition of phylogenetic profiles / A. Franceschini, J. Lin, C. von Mering, L.J. Jensen. - In: BIOINFORMATICS. - ISSN 1367-4803. - 32:7(2016 Apr), pp. 1085-1087.
SVD-phy : improved prediction of protein functional associations through singular value decomposition of phylogenetic profiles
J. LinSecondo
;
2016
Abstract
A successful approach for predicting functional associations between non-homologous genes is to compare their phylogenetic distributions. We have devised a phylogenetic profiling algorithm, SVD-Phy, which uses truncated singular value decomposition to address the problem of uninformative profiles giving rise to false positive predictions. Benchmarking the algorithm against the KEGG pathway database, we found that it has substantially improved performance over existing phylogenetic profiling methods.File | Dimensione | Formato | |
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