The ENIGMA Consortium : large-scale collaborative analyses of neuroimaging and genetic data

Thompson, P.M.; Stein, J.L.; Medland, S.E.; Hibar, D.P.; Vasquez, A.A.; Renteria, M.E.; Toro, R.; Jahanshad, N.; Schumann, G.; Franke, B.; Wright, M.J.; Martin, N.G.; Agartz, I.; Alda, M.; Alhusaini, S.; Almasy, L.; Almeida, J.; Alpert, K.; Andreasen, N.C.; Andreassen, O.A.; Apostolova, L.G.; Appel, K.; Armstrong, N.J.; Aribisala, B.; Bastin, M.E.; Bauer, M.; Bearden, C.E.; Bergmann, Ø.; Binder, E.B.; Blangero, J.; Bockholt, H.J.; Bøen, E.; Bois, C.; Boomsma, D.I.; Booth, T.; Bowman, I.J.; Bralten, J.; Brouwer, R.M.; Brunner, H.G.; Brohawn, D.G.; Buckner, R.L.; Buitelaar, J.; Bulayeva, K.; Bustillo, J.R.; Calhoun, V.D.; Cannon, D.M.; Cantor, R.M.; Carless, M.A.; Caseras, X.; Cavalleri, G.L.; Chakravarty, M..M.; Chang, K.D.; Ching, C.R.K.; Christoforou, A.; Cichon, S.; Clark, V.P.; Conrod, P.; Coppola, G.; Crespo Facorro, B.; Curran, J.E.; Czisch, M.; Deary, I.J.; de Geus, E.J.C.; den Braber, A.; Delvecchio, G.; Depondt, C.; de Haan, L.; de Zubicaray, G.I.; Dima, D.; Dimitrova, R.; Djurovic, S.; Dong, H.; Donohoe, G.; Duggirala, R.; Dyer, T.D.; Ehrlich, S.; Ekman, C.J.; Elvsåshagen, T.; Emsell, L.; Erk, S.; Espeseth, T.; Fagerness, J.; Fears, S.; Fedko, I.; Fernández, G.; Fisher, S.E.; Foroud, T.; Fox, P.T.; Francks, C.; Frangou, S.; Frey, E.M.; Frodl, T.; Frouin, V.; Garavan, H.; Giddaluru, S.; Glahn, D.C.; Godlewska, B.; Goldstein, R.Z.; Gollub, R.L.; Grabe, H.J.; Grimm, O.; Gruber, O.; Guadalupe, T.; Gur, R.E.; Gur, R.C.; Göring, H.H.H.; Hagenaars, S.; Hajek, T.; Hall, G.B.; Hall, J.; Hardy, J.; Hartman, C.A.; Hass, J.; Hatton, S.N.; Haukvik, U.K.; Hegenscheid, K.; Heinz, A.; Hickie, I.B.; Ho, B.; Hoehn, D.; Hoekstra, P.J.; Hollinshead, M.; Holmes, A.J.; Homuth, G.; Hoogman, M.; Hong, L.E.; Hosten, N.; Hottenga, J.; Hulshoff Pol, H.E.; Hwang, K.S.; J. J. Clifford R.,; Jenkinson, M.; Johnston, C.; Jönsson, E.G.; Kahn, R.S.; Kasperaviciute, D.; Kelly, S.; Kim, S.; Kochunov, P.; Koenders, L.; Krämer, B.; Kwok, J.B.J.; Lagopoulos, J.; Laje, G.; Landen, M.; Landman, B.A.; Lauriello, J.; Lawrie, S.M.; Lee, P.H.; Le Hellard, S.; Lemaître, H.; Leonardo, C.D.; Li, C.; Liberg, B.; Liewald, D.C.; Liu, X.; Lopez, L.M.; Loth, E.; Lourdusamy, A.; Luciano, M.; Macciardi, F.; Machielsen, M.W.J.; Macqueen, G.M.; Malt, U.F.; Mandl, R.; Manoach, D.S.; Martinot, J.; Matarin, M.; Mather, K.A.; Mattheisen, M.; Mattingsdal, M.; Meyer Lindenberg, A.; Mcdonald, C.; Mcintosh, A.M.; Mcmahon, F.J.; Mcmahon, K.L.; Meisenzahl, E.; Melle, I.; Milaneschi, Y.; Mohnke, S.; Montgomery, G.W.; Morris, D.W.; Moses, E.K.; Mueller, B.A.; Muñoz Maniega, S.; Mühleisen, T.W.; Müller Myhsok, B.; Mwangi, B.; Nauck, M.; Nho, K.; Nichols, T.E.; Nilsson, L.; Nugent, A.C.; Nyberg, L.; Olvera, R.L.; Oosterlaan, J.; Ophoff, R.A.; Pandolfo, M.; Papalampropoulou Tsiridou, M.; Papmeyer, M.; Paus, T.; Pausova, Z.; Pearlson, G.D.; Penninx, B.W.; Peterson, C.P.; Pfennig, A.; Phillips, M.; Pike, G.B.; Poline, J.; Potkin, S.G.; Pütz, B.; Ramasamy, A.; Rasmussen, J.; Rietschel, M.; Rijpkema, M.; Risacher, S.L.; Roffman, J.L.; Roiz Santiañez, R.; Romanczuk Seiferth, N.; Rose, E.J.; Royle, N.A.; Rujescu, D.; Ryten, M.; Sachdev, P.S.; Salami, A.; Satterthwaite, T.D.; Savitz, J.; Saykin, A.J.; Scanlon, C.; Schmaal, L.; Schnack, H.G.; Schork, A.J.; Schulz, S.C.; Schür, R.; Seidman, L.; Shen, L.; Shoemaker, J.M.; Simmons, A.; Sisodiya, S.M.; Smith, C.; Smoller, J.W.; Soares, J.C.; Sponheim, S.R.; Sprooten, E.; Starr, J.M.; Steen, V.M.; Strakowski, S.; Strike, L.; Sussmann, J.; Sämann, P.G.; Teumer, A.; Toga, A.W.; Tordesillas Gutierrez, D.; Trabzuni, D.; Trost, S.; Turner, J.; Van den Heuvel, M.; van der Wee, N.J.; van Eijk, K.; van Erp, T.G.M.; van Haren, N.E.M.; van 't Ent, D.; van Tol, M.; Valdés Hernández, M.C.; Veltman, D.J.; Versace, A.; Völzke, H.; Walker, R.; Walter, H.; Wang, L.; Wardlaw, J.M.; Weale, M.E.; Weiner, M.W.; Wen, W.; Westlye, L.T.; Whalley, H.C.; Whelan, C.D.; White, T.; Winkler, A.M.; Wittfeld, K.; Woldehawariat, G.; Wolf, C.; Zilles, D.; Zwiers, M.P.; Thalamuthu, A.; Schofield, P.R.; Freimer, N.B.; Lawrence, N.S.; Drevets, W.

doi:10.1007/s11682-013-9269-5

The Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) Consortium is a collaborative network of researchers working together on a range of large-scale studies that integrate data from 70 institutions worldwide. Organized into Working Groups that tackle questions in neuroscience, genetics, and medicine, ENIGMA studies have analyzed neuroimaging data from over 12,826 subjects. In addition, data from 12,171 individuals were provided by the CHARGE consortium for replication of findings, in a total of 24,997 subjects. By meta-analyzing results from many sites, ENIGMA has detected factors that affect the brain that no individual site could detect on its own, and that require larger numbers of subjects than any individual neuroimaging study has currently collected. ENIGMA's first project was a genome-wide association study identifying common variants in the genome associated with hippocampal volume or intracranial volume. Continuing work is exploring genetic associations with subcortical volumes (ENIGMA2) and white matter microstructure (ENIGMA-DTI). Working groups also focus on understanding how schizophrenia, bipolar illness, major depression and attention deficit/hyperactivity disorder (ADHD) affect the brain. We review the current progress of the ENIGMA Consortium, along with challenges and unexpected discoveries made on the way.

The ENIGMA Consortium : large-scale collaborative analyses of neuroimaging and genetic data / P.M. Thompson, J.L. Stein, S.E. Medland, D.P. Hibar, A.A. Vasquez, M.E. Renteria, R. Toro, N. Jahanshad, G. Schumann, B. Franke, M.J. Wright, N.G. Martin, I. Agartz, M. Alda, S. Alhusaini, L. Almasy, J. Almeida, K. Alpert, N.C. Andreasen, O.A. Andreassen, L.G. Apostolova, K. Appel, N.J. Armstrong, B. Aribisala, M.E. Bastin, M. Bauer, C.E. Bearden, Ø. Bergmann, E.B. Binder, J. Blangero, H.J. Bockholt, E. Bøen, C. Bois, D.I. Boomsma, T. Booth, I.J. Bowman, J. Bralten, R.M. Brouwer, H.G. Brunner, D.G. Brohawn, R.L. Buckner, J. Buitelaar, K. Bulayeva, J.R. Bustillo, V.D. Calhoun, D.M. Cannon, R.M. Cantor, M.A. Carless, X. Caseras, G.L. Cavalleri, M..M. Chakravarty, K.D. Chang, C.R.K. Ching, A. Christoforou, S. Cichon, V.P. Clark, P. Conrod, G. Coppola, B. Crespo-Facorro, J.E. Curran, M. Czisch, I.J. Deary, E.J.C. de Geus, A. den Braber, G. Delvecchio, C. Depondt, L. de Haan, G.I. de Zubicaray, D. Dima, R. Dimitrova, S. Djurovic, H. Dong, G. Donohoe, R. Duggirala, T.D. Dyer, S. Ehrlich, C.J. Ekman, T. Elvsåshagen, L. Emsell, S. Erk, T. Espeseth, J. Fagerness, S. Fears, I. Fedko, G. Fernández, S.E. Fisher, T. Foroud, P.T. Fox, C. Francks, S. Frangou, E.M. Frey, T. Frodl, V. Frouin, H. Garavan, S. Giddaluru, D.C. Glahn, B. Godlewska, R.Z. Goldstein, R.L. Gollub, H.J. Grabe, O. Grimm, O. Gruber, T. Guadalupe, R.E. Gur, R.C. Gur, H.H.H. Göring, S. Hagenaars, T. Hajek, G.B. Hall, J. Hall, J. Hardy, C.A. Hartman, J. Hass, S.N. Hatton, U.K. Haukvik, K. Hegenscheid, A. Heinz, I.B. Hickie, B. Ho, D. Hoehn, P.J. Hoekstra, M. Hollinshead, A.J. Holmes, G. Homuth, M. Hoogman, L.E. Hong, N. Hosten, J. Hottenga, H.E. Hulshoff Pol, K.S. Hwang, J.J. Clifford R., M. Jenkinson, C. Johnston, E.G. Jönsson, R.S. Kahn, D. Kasperaviciute, S. Kelly, S. Kim, P. Kochunov, L. Koenders, B. Krämer, J.B.J. Kwok, J. Lagopoulos, G. Laje, M. Landen, B.A. Landman, J. Lauriello, S.M. Lawrie, P.H. Lee, S. Le Hellard, H. Lemaître, C.D. Leonardo, C. Li, B. Liberg, D.C. Liewald, X. Liu, L.M. Lopez, E. Loth, A. Lourdusamy, M. Luciano, F. Macciardi, M.W.J. Machielsen, G.M. Macqueen, U.F. Malt, R. Mandl, D.S. Manoach, J. Martinot, M. Matarin, K.A. Mather, M. Mattheisen, M. Mattingsdal, A. Meyer-Lindenberg, C. Mcdonald, A.M. Mcintosh, F.J. Mcmahon, K.L. Mcmahon, E. Meisenzahl, I. Melle, Y. Milaneschi, S. Mohnke, G.W. Montgomery, D.W. Morris, E.K. Moses, B.A. Mueller, S. Muñoz Maniega, T.W. Mühleisen, B. Müller-Myhsok, B. Mwangi, M. Nauck, K. Nho, T.E. Nichols, L. Nilsson, A.C. Nugent, L. Nyberg, R.L. Olvera, J. Oosterlaan, R.A. Ophoff, M. Pandolfo, M. Papalampropoulou-Tsiridou, M. Papmeyer, T. Paus, Z. Pausova, G.D. Pearlson, B.W. Penninx, C.P. Peterson, A. Pfennig, M. Phillips, G.B. Pike, J. Poline, S.G. Potkin, B. Pütz, A. Ramasamy, J. Rasmussen, M. Rietschel, M. Rijpkema, S.L. Risacher, J.L. Roffman, R. Roiz-Santiañez, N. Romanczuk-Seiferth, E.J. Rose, N.A. Royle, D. Rujescu, M. Ryten, P.S. Sachdev, A. Salami, T.D. Satterthwaite, J. Savitz, A.J. Saykin, C. Scanlon, L. Schmaal, H.G. Schnack, A.J. Schork, S.C. Schulz, R. Schür, L. Seidman, L. Shen, J.M. Shoemaker, A. Simmons, S.M. Sisodiya, C. Smith, J.W. Smoller, J.C. Soares, S.R. Sponheim, E. Sprooten, J.M. Starr, V.M. Steen, S. Strakowski, L. Strike, J. Sussmann, P.G. Sämann, A. Teumer, A.W. Toga, D. Tordesillas-Gutierrez, D. Trabzuni, S. Trost, J. Turner, M. Van den Heuvel, N.J. van der Wee, K. van Eijk, T.G.M. van Erp, N.E.M. van Haren, D. van 't Ent, M. van Tol, M.C. Valdés Hernández, D.J. Veltman, A. Versace, H. Völzke, R. Walker, H. Walter, L. Wang, J.M. Wardlaw, M.E. Weale, M.W. Weiner, W. Wen, L.T. Westlye, H.C. Whalley, C.D. Whelan, T. White, A.M. Winkler, K. Wittfeld, G. Woldehawariat, C. Wolf, D. Zilles, M.P. Zwiers, A. Thalamuthu, P.R. Schofield, N.B. Freimer, N.S. Lawrence, W. Drevets. - In: BRAIN IMAGING AND BEHAVIOR. - ISSN 1931-7557. - 8:2(2014), pp. 153-182.

The ENIGMA Consortium : large-scale collaborative analyses of neuroimaging and genetic data

P. M. Thompson;J. L. Stein;S. E. Medland;D. P. Hibar;A. A. Vasquez;M. E. Renteria;R. Toro;N. Jahanshad;G. Schumann;B. Franke;M. J. Wright;N. G. Martin;I. Agartz;M. Alda;S. Alhusaini;L. Almasy;J. Almeida;K. Alpert;N. C. Andreasen;O. A. Andreassen;L. G. Apostolova;K. Appel;N. J. Armstrong;B. Aribisala;M. E. Bastin;M. Bauer;C. E. Bearden;Ø. Bergmann;E. B. Binder;J. Blangero;H. J. Bockholt;E. Bøen;C. Bois;D. I. Boomsma;T. Booth;I. J. Bowman;J. Bralten;R. M. Brouwer;H. G. Brunner;D. G. Brohawn;R. L. Buckner;J. Buitelaar;K. Bulayeva;J. R. Bustillo;V. D. Calhoun;D. M. Cannon;R. M. Cantor;M. A. Carless;X. Caseras;G. L. Cavalleri;M. . M. Chakravarty;K. D. Chang;C. R. K. Ching;A. Christoforou;S. Cichon;V. P. Clark;P. Conrod;G. Coppola;B. Crespo Facorro;J. E. Curran;M. Czisch;I. J. Deary;E. J. C. de Geus;A. den Braber;G. Delvecchio;C. Depondt;L. de Haan;G. I. de Zubicaray;D. Dima;R. Dimitrova;S. Djurovic;H. Dong;G. Donohoe;R. Duggirala;T. D. Dyer;S. Ehrlich;C. J. Ekman;T. Elvsåshagen;L. Emsell;S. Erk;T. Espeseth;J. Fagerness;S. Fears;I. Fedko;G. Fernández;S. E. Fisher;T. Foroud;P. T. Fox;C. Francks;S. Frangou;E. M. Frey;T. Frodl;V. Frouin;H. Garavan;S. Giddaluru;D. C. Glahn;B. Godlewska;R. Z. Goldstein;R. L. Gollub;H. J. Grabe;O. Grimm;O. Gruber;T. Guadalupe;R. E. Gur;R. C. Gur;H. H. H. Göring;S. Hagenaars;T. Hajek;G. B. Hall;J. Hall;J. Hardy;C. A. Hartman;J. Hass;S. N. Hatton;U. K. Haukvik;K. Hegenscheid;A. Heinz;I. B. Hickie;B. Ho;D. Hoehn;P. J. Hoekstra;M. Hollinshead;A. J. Holmes;G. Homuth;M. Hoogman;L. E. Hong;N. Hosten;J. Hottenga;H. E. Hulshoff Pol;K. S. Hwang;J. J. Clifford R.;M. Jenkinson;C. Johnston;E. G. Jönsson;R. S. Kahn;D. Kasperaviciute;S. Kelly;S. Kim;P. Kochunov;L. Koenders;B. Krämer;J. B. J. Kwok;J. Lagopoulos;G. Laje;M. Landen;B. A. Landman;J. Lauriello;S. M. Lawrie;P. H. Lee;S. Le Hellard;H. Lemaître;C. D. Leonardo;C. Li;B. Liberg;D. C. Liewald;X. Liu;L. M. Lopez;E. Loth;A. Lourdusamy;M. Luciano;F. Macciardi;M. W. J. Machielsen;G. M. Macqueen;U. F. Malt;R. Mandl;D. S. Manoach;J. Martinot;M. Matarin;K. A. Mather;M. Mattheisen;M. Mattingsdal;A. Meyer Lindenberg;C. Mcdonald;A. M. Mcintosh;F. J. Mcmahon;K. L. Mcmahon;E. Meisenzahl;I. Melle;Y. Milaneschi;S. Mohnke;G. W. Montgomery;D. W. Morris;E. K. Moses;B. A. Mueller;S. Muñoz Maniega;T. W. Mühleisen;B. Müller Myhsok;B. Mwangi;M. Nauck;K. Nho;T. E. Nichols;L. Nilsson;A. C. Nugent;L. Nyberg;R. L. Olvera;J. Oosterlaan;R. A. Ophoff;M. Pandolfo;M. Papalampropoulou Tsiridou;M. Papmeyer;T. Paus;Z. Pausova;G. D. Pearlson;B. W. Penninx;C. P. Peterson;A. Pfennig;M. Phillips;G. B. Pike;J. Poline;S. G. Potkin;B. Pütz;A. Ramasamy;J. Rasmussen;M. Rietschel;M. Rijpkema;S. L. Risacher;J. L. Roffman;R. Roiz Santiañez;N. Romanczuk Seiferth;E. J. Rose;N. A. Royle;D. Rujescu;M. Ryten;P. S. Sachdev;A. Salami;T. D. Satterthwaite;J. Savitz;A. J. Saykin;C. Scanlon;L. Schmaal;H. G. Schnack;A. J. Schork;S. C. Schulz;R. Schür;L. Seidman;L. Shen;J. M. Shoemaker;A. Simmons;S. M. Sisodiya;C. Smith;J. W. Smoller;J. C. Soares;S. R. Sponheim;E. Sprooten;J. M. Starr;V. M. Steen;S. Strakowski;L. Strike;J. Sussmann;P. G. Sämann;A. Teumer;A. W. Toga;D. Tordesillas Gutierrez;D. Trabzuni;S. Trost;J. Turner;M. Van den Heuvel;N. J. van der Wee;K. van Eijk;T. G. M. van Erp;N. E. M. van Haren;D. van 't Ent;M. van Tol;M. C. Valdés Hernández;D. J. Veltman;A. Versace;H. Völzke;R. Walker;H. Walter;L. Wang;J. M. Wardlaw;M. E. Weale;M. W. Weiner;W. Wen;L. T. Westlye;H. C. Whalley;C. D. Whelan;T. White;A. M. Winkler;K. Wittfeld;G. Woldehawariat;C. Wolf;D. Zilles;M. P. Zwiers;A. Thalamuthu;P. R. Schofield;N. B. Freimer;N. S. Lawrence;W. Drevets

2014

Abstract

The Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) Consortium is a collaborative network of researchers working together on a range of large-scale studies that integrate data from 70 institutions worldwide. Organized into Working Groups that tackle questions in neuroscience, genetics, and medicine, ENIGMA studies have analyzed neuroimaging data from over 12,826 subjects. In addition, data from 12,171 individuals were provided by the CHARGE consortium for replication of findings, in a total of 24,997 subjects. By meta-analyzing results from many sites, ENIGMA has detected factors that affect the brain that no individual site could detect on its own, and that require larger numbers of subjects than any individual neuroimaging study has currently collected. ENIGMA's first project was a genome-wide association study identifying common variants in the genome associated with hippocampal volume or intracranial volume. Continuing work is exploring genetic associations with subcortical volumes (ENIGMA2) and white matter microstructure (ENIGMA-DTI). Working groups also focus on understanding how schizophrenia, bipolar illness, major depression and attention deficit/hyperactivity disorder (ADHD) affect the brain. We review the current progress of the ENIGMA Consortium, along with challenges and unexpected discoveries made on the way.

Scheda breve

Scheda completa

Scheda completa (DC)

	Parole chiave
	
			Consortium; Genetics; GWAS; Meta-analysis; MRI; Multi-site; Brain Mapping; Cooperative Behavior; Genome-Wide Association Study; Humans; Meta-Analysis as Topic; Neuroimaging; Radiology, Nuclear Medicine and Imaging; Behavioral Neuroscience; Cellular and Molecular Neuroscience; Cognitive Neuroscience; Neurology; Psychiatry and Mental Health; Neurology (clinical)
		
	Settori scientifico-disciplinari dell'articolo
	
			Settore MED/03 - Genetica Medica
Settore MED/25 - Psichiatria
Settore MED/37 - Neuroradiologia
		
	Data di pubblicazione
	
			2014
		
	Rivista in ANCE
	
			BRAIN IMAGING AND BEHAVIOR
		
	DOI
	
			https://dx.doi.org/10.1007/s11682-013-9269-5
		
	Tipologia
	
			Article (author)
		
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			01 - Articolo su periodico

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