A short synthetic strategy for the preparation of the alpha-D-glucopyranosyl-(1 -> 2)-beta-D-galactopyranosyl-O-pyridinoline (Glc-Gat-PYD), of the alpha-D-glucopyranosyl-(1 -> 2)-beta-D-galactopyranosyl-5-O-hydroxylysine (Glc-Gal-Hyl) and of their respective epimers, Glc-Gal-epiPYD and Glc-Gal-epiHyl, useful for the analytical evaluation of collagen biomarkers in human sinovium and bone, is reported.

A simple strategy for the synthesis of the glycosylated collagen biomarkers alfa-D-glucopyranosyl-(1->2)-beta-D-galactopyranosyl-O-pyridinoline (Glc-Gal-PYD), alfa-D-glucopyranosyl-(1->2)-beta-D-galactopyranosyl-5-O-hydroxylysine (Glc-Gal-Hyl) and of their unnatural epimers Glc-Gal-epiPYD and Glc-Gal-epiHyl / P. Allevi, E.A. Femia, E. Giannini, M. Anastasia. - In: TETRAHEDRON-ASYMMETRY. - ISSN 0957-4166. - 18:22(2007 Nov 12), pp. 2689-2694. [10.1016/j.tetasy.2007.10.037]

A simple strategy for the synthesis of the glycosylated collagen biomarkers alfa-D-glucopyranosyl-(1->2)-beta-D-galactopyranosyl-O-pyridinoline (Glc-Gal-PYD), alfa-D-glucopyranosyl-(1->2)-beta-D-galactopyranosyl-5-O-hydroxylysine (Glc-Gal-Hyl) and of their unnatural epimers Glc-Gal-epiPYD and Glc-Gal-epiHyl

P. Allevi;E.A. Femia;E. Giannini;M. Anastasia
2007-11-12

Abstract

A short synthetic strategy for the preparation of the alpha-D-glucopyranosyl-(1 -> 2)-beta-D-galactopyranosyl-O-pyridinoline (Glc-Gat-PYD), of the alpha-D-glucopyranosyl-(1 -> 2)-beta-D-galactopyranosyl-5-O-hydroxylysine (Glc-Gal-Hyl) and of their respective epimers, Glc-Gal-epiPYD and Glc-Gal-epiHyl, useful for the analytical evaluation of collagen biomarkers in human sinovium and bone, is reported.
Glucosyl-glactosyl-pyridinoline ; osteoarthritis ; hydroxylysine
Settore BIO/10 - Biochimica
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/35599
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