We present a case of severe, irreversible neurotoxicity in a 55-year-old-patient with myelofibrosis undergoing hematopoietic stem cell transplantation following a reduced intensity conditioning including fludarabine. The patient developed progressive sensory-motor, visual and consciousness disturbances, eventually leading to death. MRI imaging pattern was unique and attributable to fludarabine neurotoxicity
Severe fludarabine neurotoxicity after reduced intensity conditioning regimen to allogeneic hematopoietic stem cell transplantation: a case report / C. Annaloro, A. Costa, N.S. Fracchiolla, G. Mometto, S. Artuso, G. Saporiti, E. Tagliaferri, F. Grifoni, F. Onida, A. Cortelezzi. - In: CLINICAL CASE REPORTS. - ISSN 2050-0904. - 3:7(2015 Jul), pp. 650-655. [10.1002/ccr3.308]
Severe fludarabine neurotoxicity after reduced intensity conditioning regimen to allogeneic hematopoietic stem cell transplantation: a case report
F. Onida;A. Cortelezzi
2015
Abstract
We present a case of severe, irreversible neurotoxicity in a 55-year-old-patient with myelofibrosis undergoing hematopoietic stem cell transplantation following a reduced intensity conditioning including fludarabine. The patient developed progressive sensory-motor, visual and consciousness disturbances, eventually leading to death. MRI imaging pattern was unique and attributable to fludarabine neurotoxicity
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