SETTING: Luigi Sacco Hospital, Milan, Italy, 1 January 2000-31 December 2010. OBJECTIVES: To develop a predictive score for identifying human immunodeficiency virus (HIV) infected patients with pulmonary tuberculosis (PTB). DESIGN: Retrospective study based on the medical charts of HIV-infected patients admitted consecutively on presumption of PTB. Patients with culture-positive TB were included in the TB group. Culture-negative subjects formed the non-TB group. Risk factors for PTB were identified and a predictive model was developed. The diagnostic test accuracy of the derived score and that of previously developed scores were analysed. RESULTS: A total of 65 patients were included in the TB group and 505 subjects in the non-TB group. An eight-variable model (age, origin, alcohol use, respiratory rate, weight loss, haemoglobin, white blood cell count, typical chest X-ray) was derived. When compared with the different scores, this model showed the greatest area under the receiver operating characteristic curve (0.880). This score was the only one to present a negative likelihood ratio of <0.2, which is the threshold for giving strong diagnostic evidence against TB. CONCLUSIONS: This model may be useful in predicting PTB in HIV patients in low-endemic countries. A validation study is necessary.
A new predictive model for an improved respiratory isolation strategy in HIV-infected patients with PTB / M. Carugati, C. Schiroli, F. Zanini, N. Vanoni, M. Galli, F. Adorni, F. Franzetti. - In: INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE. - ISSN 1027-3719. - 18:7(2014 Jul 01), pp. 831-836.
|Titolo:||A new predictive model for an improved respiratory isolation strategy in HIV-infected patients with PTB|
CARUGATI, MANUELA (Corresponding)
SCHIROLI, CONSUELO (Secondo)
|Parole Chiave:||Diagnosis; Mycobacterium tuberculosis; Score; Adult; Female; HIV Infections; Humans; Italy; Likelihood Functions; Male; Predictive Value of Tests; ROC Curve; Retrospective Studies; Risk Factors; Tuberculosis, Pulmonary; Models, Statistical; Pulmonary and Respiratory Medicine; Infectious Diseases; Medicine (all)|
|Settore Scientifico Disciplinare:||Settore MED/17 - Malattie Infettive|
|Data di pubblicazione:||1-lug-2014|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.5588/ijtld.13.0588|
|Appare nelle tipologie:||01 - Articolo su periodico|