Altered peripheral myelination in mice lacking GABAB receptors

Magnaghi, V.; Ballabio, M.; Camozzi, F.; Colleoni, M.; Consoli, A.; Gassmann, M.; Lauria, G.; Motta, M.; Procacci, P.; Trovato, A.E.; Bettler, B.

doi:10.1016/j.mcn.2007.12.009

Emerging evidence implicates gamma-aminobutyric acid type B (GABA(B)) receptors in peripheral nervous system (PNS) functions. In order to elucidate which biochemical, morphological and functional parameters of peripheral nerve fibers depend on GABA(B) receptors we studied GABA(B1)-deficient mice, which are devoid of functional GABA(B) receptors. Here, we show that GABA(B1)-deficient mice exhibit morphological and molecular changes in peripheral myelin, including an increase in the number of irregular fibers and increases in the expression levels of the myelin proteins PMP22 and P0. Moreover, the number of small myelinated fibers and small neurons of the lumbar dorsal root ganglia is higher in GABA(B1)-deficient mice than in wild-type littermates. We further show that GABA(B1)-deficient mice exhibit gait alterations and reduced allodynia. In summary, our findings implicate GABA(B) receptors in the PNS myelination process and raise the possibility that PNS alterations contribute to the sensory phenotypes of GABA(B1)-deficient mice.

Altered peripheral myelination in mice lacking GABAB receptors / V. Magnaghi, M. Ballabio, F. Camozzi, M. Colleoni, A. Consoli, M. Gassmann, G. Lauria, M. Motta, P. Procacci, A.E. Trovato, B. Bettler. - In: MOLECULAR AND CELLULAR NEUROSCIENCES. - ISSN 1044-7431. - 37:3(2008 Mar), pp. 599-609.

Titolo:	Altered peripheral myelination in mice lacking GABAB receptors
Autori:	MAGNAGHI, VALERIO BALLABIO, MARINELLA F. Camozzi COLLEONI, MARIAPIA CONSOLI, ANTONIO M. Gassmann LAURIA PINTER, GIUSEPPE MOTTA, MARCELLA PROCACCI, PATRIZIA TROVATO, ANNA ELISA B. Bettler mostra contributor esterni nascondi contributor esterni
Parole Chiave:	Aδ fibers; DRG; Nociception; P0; PMP22; Sciatic nerve
Settore Scientifico Disciplinare:	Settore MED/13 - Endocrinologia Settore BIO/09 - Fisiologia Settore BIO/17 - Istologia Settore BIO/14 - Farmacologia Settore MED/26 - Neurologia
Data di pubblicazione:	mar-2008
Rivista:	MOLECULAR AND CELLULAR NEUROSCIENCES
Tipologia:	Article (author)
Digital Object Identifier (DOI):	http://dx.doi.org/10.1016/j.mcn.2007.12.009
Appare nelle tipologie:	01 - Articolo su periodico

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