In this study we examined the effects of the glutamate metabotropic subtype 5 (mGlu5) receptor antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP) on Fos expression in the spinal cord in a model of visceral pain in the rat. We show that noxious stimulation increases the number of Fos-positive neurons in the dorsal horn of the thoracic and lumbar spinal cord, and that pretreatment with MPEP significantly reduces the number of Fos-positive neurons in these areas. These data indicate that mGlu5 is involved in the transmission of visceral pain in the spinal cord.
mGlu5 receptor antagonist decreases Fos expression in spinal neurons after noxious visceral stimulation / R. Bianchi, R. Rezzani, E. Borsani, L. Rodella. - In: BRAIN RESEARCH. - ISSN 0006-8993. - 960:1-2(2003 Jan 17), pp. 263-266.
mGlu5 receptor antagonist decreases Fos expression in spinal neurons after noxious visceral stimulation
R. BianchiPrimo
;
2003
Abstract
In this study we examined the effects of the glutamate metabotropic subtype 5 (mGlu5) receptor antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP) on Fos expression in the spinal cord in a model of visceral pain in the rat. We show that noxious stimulation increases the number of Fos-positive neurons in the dorsal horn of the thoracic and lumbar spinal cord, and that pretreatment with MPEP significantly reduces the number of Fos-positive neurons in these areas. These data indicate that mGlu5 is involved in the transmission of visceral pain in the spinal cord.Pubblicazioni consigliate
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