Down syndrome (DS) is generally considered as an "atheroma-free model". In this preliminary study, we investigated homocysteine, folate and Vitamin B-12 levels in 13 DS patients (male, average age 60 years) and 20 age-matched individuals. We also studied lipid fractions, and polymorphisms for Cystothionine beta-synthase (CBS), 5,10-methyl-tetrahydro-folate reductase (MTHFR) and apolipoprotein E (Apo-E) genes. However, DS patients with the MTHFR TT genotype showed an increased of plasma homocysteine (tHcy). Our results indicate that this group of "healthy old" Down syndrome patients, although showing some classical biochemical risk factors for atherosclerosis, did not suffer clinical cardiovascular alterations.
Does Down's syndrome support the homocysteine theory of atherogenesis? Experience in elderly subjects with trisomy 21 / F. Licastro, A. Marocchi, S. Penco, E. Porcellini, D. Lio, G. Dogliotti, M.M. Corsi. - 43:3(2006 Dec), pp. 381-387.
|Titolo:||Does Down's syndrome support the homocysteine theory of atherogenesis? Experience in elderly subjects with trisomy 21|
DOGLIOTTI, GIADA (Penultimo)
CORSI ROMANELLI, MASSIMILIANO MARCO (Ultimo)
|Parole Chiave:||Down syndrome ; homocysteine ; foliate ; vitamin B-12 ; cystothionine beta-synthase (CBS) ; 5,10-methyl-tetrahydro-folate reductase (MTRFR) ; Apo-A ; Apo-B ; Apo epsilon 4|
|Settore Scientifico Disciplinare:||Settore MED/05 - Patologia Clinica|
|Data di pubblicazione:||dic-2006|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.archger.2006.01.003|
|Appare nelle tipologie:||01 - Articolo su periodico|