Summary A cytoplasmic antigen associated to inosine-5'-monophosphatedehydrogenase 2 eliciting specific antibodies (antirods and rings, RR) has been identified in patients with chronic hepatitis C who were exposed to pegylated interferon (PI) and ribavirin (RBV). The significance of anti-RR in these patients merits to be investigated. Sera from 88 chronic hepatitis C virus (HCV)-infected patients undergoing PI-RBV therapy were analysed for the presence of RR pattern by indirect immunofluorescence on HEp-2 substrate (Inova Diagnostics, San Diego, CA, USA). Anti-RR antibodies developed de novo in 32 patients independently of any demographic and virological feature, but with a significant association with cumulative exposure to PI-RBV (P = 0.0089; chi-square test). RR pattern was significantly more frequent in relapsers than in patients achieving sustained virological response (56% vs 30%; P = 0.0282, chi-square test). Anti-RR titre ranged from 1:80 to 1:1280, but significantly declined following treatment cessation. Anti-RR develop de novo in a substantial proportion of patients exposed to PI-RBV in relation to the duration of treatment exposure. Further investigations are necessary to unravel the mechanisms leading to the formation of these autoantibodies.
Interferon-ribavirin therapy induces serum antibodies determining 'rods and rings' pattern in hepatitis C patients / C. Novembrino, A. Aghemo, C. Ferraris Fusarini, R. Maiavacca, C. Matinato, G. Lunghi, E. Torresani, M. Ronchi, M.C. Garlaschi, M. Ramondetta, M. Colombo. - In: JOURNAL OF VIRAL HEPATITIS. - ISSN 1352-0504. - 21:12(2014), pp. 944-949.
|Titolo:||Interferon-ribavirin therapy induces serum antibodies determining 'rods and rings' pattern in hepatitis C patients|
NOVEMBRINO, CRISTINA (Corresponding)
AGHEMO, ALESSIO MICHELE (Secondo)
RAMONDETTA, MIRIAM (Penultimo)
COLOMBO, MASSIMO GIUSEPPE (Ultimo)
|Parole Chiave:||autoantibodies; hepatitis C virus; inosine-5'-monophosphatedehydrogenase 2; interferon; ribavirin; Adult; Aged; Antiviral Agents; Autoantibodies; Female; Fluorescent Antibody Technique, Indirect; Hepatitis C, Chronic; Humans; IMP Dehydrogenase; Interferons; Longitudinal Studies; Male; Middle Aged; Retrospective Studies; Ribavirin; Young Adult; Hepatology; Infectious Diseases; Virology; Medicine (all)|
|Settore Scientifico Disciplinare:||Settore MED/12 - Gastroenterologia|
|Data di pubblicazione:||2014|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1111/jvh.12281|
|Appare nelle tipologie:||01 - Articolo su periodico|