Although being a monolayer the vascular endothelium controls fundamental vessel functions such as permeability, leukocyte extravasation and angiogenesis. The endothelial selective transmembrane constituent of adherens junctions, Vascular Endothelial- (VE-) cadherin plays a crucial role in the regulation of such activities. The signaling pathways controlled by VE-cadherin as well as the ones that regulate VE-cadherin activity start to be elucidated. This delineates a complex network of molecular and functional interactions that can be altered in pathologies.
VE-cadherin at a glance / L. Bravi, E. Dejana, M.G. Lampugnani. - In: CELL AND TISSUE RESEARCH. - ISSN 0302-766X. - 355:3(2014), pp. 515-522.
Titolo: | VE-cadherin at a glance |
Autori: | BRAVI, LUCA (Primo) DEJANA, ELISABETTA (Secondo) |
Parole Chiave: | Angiogenesis; Cell-to-cell junctions; Endothelium; Permeability; VE-cadherin; Animals; Antigens, CD; Cadherins; Humans; 2734; Cell Biology; Histology; Medicine (all) |
Settore Scientifico Disciplinare: | Settore MED/04 - Patologia Generale |
Data di pubblicazione: | 2014 |
Rivista: | |
Tipologia: | Article (author) |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1007/s00441-014-1843-7 |
Appare nelle tipologie: | 01 - Articolo su periodico |
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