The interrelationship between IgAs and microbiota diversity is still unclear. Here we show that BALB/c mice had higher abundance and diversity of IgAs than C57BL/6 mice and that this correlated with increased microbiota diversity. We show that polyreactive IgAs mediated the entrance of non-invasive bacteria to Peyer's patches, independently of CX3CR1+ phagocytes. This allowed the induction of bacteria-specific IgA and the establishment of a positive feedback loop of IgA production. Cohousing of mice or fecal transplantation had little or no influence on IgA production and had only partial impact on microbiota composition. Germ-free BALB/c, but not C57BL/6, mice already had polyreactive IgAs that influenced microbiota diversity and selection after colonization. Together, these data suggest that genetic predisposition to produce polyreactive IgAs has a strong impact on the generation of antigen-specific IgAs and the selection and maintenance of microbiota diversity.
BALB/c and C57BL/6 Mice Differ in Polyreactive IgA Abundance, which Impacts the Generation of Antigen-Specific IgA and Microbiota Diversity / F. Fransen, E. Zagato, E. Mazzini, B. Fosso, C. Manzari, S. El Aidy, A. Chiavelli, A.M. D'Erchia, M.K. Sethi, O. Pabst, M. Marzano, S. Moretti, L. Romani, G. Penna, G. Pesole, M. Rescigno. - In: IMMUNITY. - ISSN 1074-7613. - 43:3(2015), pp. 527-540.
Titolo: | BALB/c and C57BL/6 Mice Differ in Polyreactive IgA Abundance, which Impacts the Generation of Antigen-Specific IgA and Microbiota Diversity |
Autori: | RESCIGNO, MARIA (Corresponding) |
Parole Chiave: | Immunology and Allergy; Infectious Diseases; Immunology |
Settore Scientifico Disciplinare: | Settore MED/04 - Patologia Generale |
Data di pubblicazione: | 2015 |
Rivista: | |
Tipologia: | Article (author) |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/j.immuni.2015.08.011 |
Appare nelle tipologie: | 01 - Articolo su periodico |
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