Prenatal stress (PNS) is a risk factor for the development of neuropsychiatric disorders. This study was aimed at assessing, in a rodent model, changes in gene expression profiles and behavioral output as a result of PNS, during periadolescence, a critical developmental period for the onset of psychopathology. Social behavior was studied in a standardized social interaction paradigm and the expression of Brain-Derived Neurotrophic Factor (Bdnf), a marker of neuronal plasticity, and of inhibitory and excitatory mechanisms (Na+-K+-2Cl-and K+-Cl- cotransporters ratio, NKCC1/KCC2) was analyzed. Results indicate that PNS reduced Bdnf transcripts while increasing the NKCC1/KCC2 ratio, primarily in the hippocampus. In the prefrontal cortex, changes in Bdnf were found to be gender-dependent. These effects were accompanied by reduced levels of affiliative and investigative social behaviors. Interestingly, interaction with non-stressed subjects was able to improve sociality in PNS rats suggesting that the social environment could be exploited for therapeutic intervention.
|Titolo:||Decreased Bdnf expression and reduced social behavior in periadolescent rats following prenatal stress|
RIVA, MARCO ANDREA (Penultimo)
|Parole Chiave:||Bdnf; Gene expression; Hippocampus; Periadolescence; Prefrontal cortex; Prenatal stress; Rats; Social behavior; Developmental Biology; Behavioral Neuroscience; Developmental Neuroscience; Developmental and Educational Psychology|
|Settore Scientifico Disciplinare:||Settore BIO/14 - Farmacologia|
|Data di pubblicazione:||apr-2015|
|Digital Object Identifier (DOI):||10.1002/dev.21297|
|Appare nelle tipologie:||01 - Articolo su periodico|