Cell permeable peptides (CPPs) represent a novel tool for the delivery of bioactive molecules into scarcely accessible organs, such as the brain. CPPs have been successfully used in pre-clinical studies for a variety of diseases, ranging from cancer to neurological disorders. However, the mechanisms by which CPPs cross biological membranes, as well as their pharmacokinetic properties, have been poorly explored due to the lack of specific and sensitive analytical methods.
Determination of tissue levels of a neuroprotectant drug : the cell permeable JNK inhibitor peptide / E. Davoli, A. Sclip, M. Cecchi, S. Cimini, A. Carrà, M. Salmona, T. Borsello. - In: JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS. - ISSN 1056-8719. - 70:1(2014), pp. 55-61. [10.1016/j.vascn.2014.04.001]
Determination of tissue levels of a neuroprotectant drug : the cell permeable JNK inhibitor peptide
T. Borsello
2014
Abstract
Cell permeable peptides (CPPs) represent a novel tool for the delivery of bioactive molecules into scarcely accessible organs, such as the brain. CPPs have been successfully used in pre-clinical studies for a variety of diseases, ranging from cancer to neurological disorders. However, the mechanisms by which CPPs cross biological membranes, as well as their pharmacokinetic properties, have been poorly explored due to the lack of specific and sensitive analytical methods.
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