Chronic ethanol (EtOH) abuse worsens pathophysiological derangements after hemorrhagic shock and resuscitation (H/R) that induce hepatic injury and strong inflammatory changes via JNK and NF-κB activation. Inhibiting JNK with a cell-penetrating, protease-resistant peptide D-JNKI-1 after H/R in mice with healthy livers ameliorated these effects. Here, we studied if JNK inhibition by D-JNKI-1 in chronically EtOH-fed mice after hemorrhagic shock prior to the onset of resuscitation also confers protection.
Differential relevance of NF-κB and JNK in the pathophysiology of hemorrhage/resususcitation-induced liver injury after chronic ethanol feeding / B. Relja, R. Weber, M. Maraslioglu, N. Wagner, T. Borsello, C. Jobin, I. Marzi, M. Lehnert. - In: PLOS ONE. - ISSN 1932-6203. - 10:9(2015), pp. e0137875.1-e0137875.17. [10.1371/journal.pone.0137875]
Differential relevance of NF-κB and JNK in the pathophysiology of hemorrhage/resususcitation-induced liver injury after chronic ethanol feeding
T. Borsello;
2015
Abstract
Chronic ethanol (EtOH) abuse worsens pathophysiological derangements after hemorrhagic shock and resuscitation (H/R) that induce hepatic injury and strong inflammatory changes via JNK and NF-κB activation. Inhibiting JNK with a cell-penetrating, protease-resistant peptide D-JNKI-1 after H/R in mice with healthy livers ameliorated these effects. Here, we studied if JNK inhibition by D-JNKI-1 in chronically EtOH-fed mice after hemorrhagic shock prior to the onset of resuscitation also confers protection.File | Dimensione | Formato | |
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