Arrhythmogenic cardiomyopathy (ACM) is a genetic disorder mainly due to mutations in desmosomal genes, characterized by progressive fibro-adipose replacement of the myocardium, arrhythmias, and sudden death. It is still unclear which cell type is responsible for fibro-adipose substitution and which molecular mechanisms lead to this structural change. Cardiac mesenchymal stromal cells (C-MSC) are the most abundant cells in the heart, with propensity to differentiate into several cell types, including adipocytes, and their role in ACM is unknown. The aim of the present study was to investigate whether C-MSC contributed to excess adipocytes in patients with ACM.
|Titolo:||Cardiac mesenchymal stromal cells are a source of adipocytes in arrhythmogenic cardiomyopathy|
|Parole Chiave:||Adipogenesis; Arrhythmogenic cardiomyopathy; Fibrofatty substitution; Mesenchymal stromal cells; Plakoglobin; Plakophilin2|
|Settore Scientifico Disciplinare:||Settore BIO/13 - Biologia Applicata|
|Data di pubblicazione:||20-nov-2015|
|Data ahead of print / Data di stampa:||20-nov-2015|
|Appare nelle tipologie:||01 - Articolo su periodico|