Ageing effects on sugar intestinal transport were studied by using the everted sac and the brush-border membrane vesicle techniques. Four age groups of rats were used: very young, young, adult and old animals. Net transintestinal transport of d-glucose and intracellular sugar accumulation were greater in young than in very young, adult and old rats. Net Na+ transport was high in very young and young animals and then it declined with age. In brush-border membrane vesicle experiments d-glucose overshoot was smaller in the groups of animals where net sugar transport was less. In old rats, however, the overshoot did not occur. Short-circuiting of vesicles with valinomycin showed that the driving forces for sugar accumulation, i.e. the chemical potential gradient of Na+ and the electrical potential gradient, played different roles during ageing. In very young animals the chemical potential gradient seems to be responsible for d-glucose overshoot; in young rats both gradients are important while in adult animals the electrical potential gradient represents the main driving force.
Intestinal sugar transport during ageing / C. Lindi, P. Marciani, A. Faelli, G. Esposito. - In: BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES. - ISSN 0005-2736. - 816:2(1985), pp. 411-414.
|Titolo:||Intestinal sugar transport during ageing|
LINDI, CLARA (Primo)
MARCIANI, PAOLA (Secondo)
FAELLI, ALIDE (Penultimo)
|Parole Chiave:||Ageing; Glucose transport; Na+ transport; Brush-border membrane; Valinomycin; (Rat intestine)|
|Settore Scientifico Disciplinare:||Settore BIO/09 - Fisiologia|
|Data di pubblicazione:||1985|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/0005-2736(85)90509-7|
|Appare nelle tipologie:||01 - Articolo su periodico|