Ageing effects on sugar intestinal transport were studied by using the everted sac and the brush-border membrane vesicle techniques. Four age groups of rats were used: very young, young, adult and old animals. Net transintestinal transport of d-glucose and intracellular sugar accumulation were greater in young than in very young, adult and old rats. Net Na+ transport was high in very young and young animals and then it declined with age. In brush-border membrane vesicle experiments d-glucose overshoot was smaller in the groups of animals where net sugar transport was less. In old rats, however, the overshoot did not occur. Short-circuiting of vesicles with valinomycin showed that the driving forces for sugar accumulation, i.e. the chemical potential gradient of Na+ and the electrical potential gradient, played different roles during ageing. In very young animals the chemical potential gradient seems to be responsible for d-glucose overshoot; in young rats both gradients are important while in adult animals the electrical potential gradient represents the main driving force.

Intestinal sugar transport during ageing / C. Lindi, P. Marciani, A. Faelli, G. Esposito. - In: BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES. - ISSN 0005-2736. - 816:2(1985), pp. 411-414.

Intestinal sugar transport during ageing

C. Lindi;P. Marciani;A. Faelli;
1985

Abstract

Ageing effects on sugar intestinal transport were studied by using the everted sac and the brush-border membrane vesicle techniques. Four age groups of rats were used: very young, young, adult and old animals. Net transintestinal transport of d-glucose and intracellular sugar accumulation were greater in young than in very young, adult and old rats. Net Na+ transport was high in very young and young animals and then it declined with age. In brush-border membrane vesicle experiments d-glucose overshoot was smaller in the groups of animals where net sugar transport was less. In old rats, however, the overshoot did not occur. Short-circuiting of vesicles with valinomycin showed that the driving forces for sugar accumulation, i.e. the chemical potential gradient of Na+ and the electrical potential gradient, played different roles during ageing. In very young animals the chemical potential gradient seems to be responsible for d-glucose overshoot; in young rats both gradients are important while in adult animals the electrical potential gradient represents the main driving force.
Ageing; Glucose transport; Na+ transport; Brush-border membrane; Valinomycin; (Rat intestine)
Settore BIO/09 - Fisiologia
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
Article (author)
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/345804
Citazioni
  • ???jsp.display-item.citation.pmc??? 2
  • Scopus 31
  • ???jsp.display-item.citation.isi??? 33
social impact