Apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 3G (APOBEC3G), a human cytidine deaminase, is a potent inhibitor of HIV replication. To explore a possible role of this protein in modulating in vivo susceptibility to HIV infection, we analyzed APOBEC3G expression in HIV-exposed seronegative individuals, HIV-seropositive patients, and healthy control subjects. The results showed that the expression of APOBEC3G is significantly increased in peripheral blood mononuclear cells (PBMCs)--mainly CD14(+) cells--and in cervical tissues of HIV-exposed seronegative individuals. Higher APOBEC3G expression correlated with a reduced susceptibility of PBMCs to in vitro infection with the HIV-1(Ba-L) R5 strain. APOBEC3G could be important in modulating in vivo susceptibility to sexually transmitted HIV infection.

Apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 3G : a possible role in the resistance to HIV of HIV-exposed seronegative individuals / M. Biasin, L. Piacentini, S. Lo Caputo, Y. Kanari, G. Magri, D. Trabattoni, V. Naddeo, L. Lopalco, A. Clivio, E. Cesana, F. Fasano, C. Bergamaschi, F. Mazzotta, M. Miyazawa, M. Clerici. - In: THE JOURNAL OF INFECTIOUS DISEASES. - ISSN 0022-1899. - 195:7(2007), pp. 960-964. [10.1086/511988]

Apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 3G : a possible role in the resistance to HIV of HIV-exposed seronegative individuals

M. Biasin;L. Piacentini;D. Trabattoni;V. Naddeo;A. Clivio;CESANA, EUGENIO;F. Fasano;BERGAMASCHI, CRISTINA;M. Clerici
2007

Abstract

Apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 3G (APOBEC3G), a human cytidine deaminase, is a potent inhibitor of HIV replication. To explore a possible role of this protein in modulating in vivo susceptibility to HIV infection, we analyzed APOBEC3G expression in HIV-exposed seronegative individuals, HIV-seropositive patients, and healthy control subjects. The results showed that the expression of APOBEC3G is significantly increased in peripheral blood mononuclear cells (PBMCs)--mainly CD14(+) cells--and in cervical tissues of HIV-exposed seronegative individuals. Higher APOBEC3G expression correlated with a reduced susceptibility of PBMCs to in vitro infection with the HIV-1(Ba-L) R5 strain. APOBEC3G could be important in modulating in vivo susceptibility to sexually transmitted HIV infection.
Settore MED/04 - Patologia Generale
Settore BIO/13 - Biologia Applicata
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/34570
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