Zaire Ebola virus (EBOV) is an enveloped non-segmented negative strand RNA virus of 19kb in length belonging to the family Filoviridae. The virus was isolated and identified in 1976 during the epidemic of hemorrhagic fever in Zaire. The most recent outbreak of EBOV among humans, was that occurred in the forested areas of south eastern Guinea, that began in February 2014 and is still ongoing. The recent Ebola outbreak, is affecting other countries in West Africa, in addiction to Guinea: Liberia, Nigeria, and Sierra Leone. In this article, a selective pressure analysis and homology modeling based on the G Glycoprotein (GP) sequences retrieved from public databases were used to investigate the genetic diversity and modification of antibody response in the recent outbreak of Ebola Virus. Structural and the evolutionary analysis underline the 2014 epidemic virus being under negative selective pressure does not change with respect to the old epidemic in terms of genome adaptation.
Amino acid mutations in Ebola virus glycoprotein of the 2014 epidemic / M. Giovanetti, A. Grifoni, A. Lo Presti, E. Cella, C. Montesano, G. Zehender, V. Colizzi, M. Amicosante, M. Ciccozzi. - In: JOURNAL OF MEDICAL VIROLOGY. - ISSN 0146-6615. - 87:6(2015 Jun), pp. 893-898.
|Titolo:||Amino acid mutations in Ebola virus glycoprotein of the 2014 epidemic|
|Parole Chiave:||Ebola virus; evolutionary analysis; glycoprotein; virology; infectious diseases|
|Settore Scientifico Disciplinare:||Settore MED/42 - Igiene Generale e Applicata|
Settore MED/17 - Malattie Infettive
|Data di pubblicazione:||giu-2015|
|Data ahead of print / Data di stampa:||17-mar-2015|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1002/jmv.24133|
|Appare nelle tipologie:||01 - Articolo su periodico|
File in questo prodotto:
|Giovanetti_et_al-2015-Journal_of_Medical_Virology.pdf||Publisher's version/PDF||Administrator Richiedi una copia|