Although 17β-estradiol (E2) anti-inflammatory activity has been well described, very little is known about the effects of this hormone on the resolution phase of the inflammatory process. Here, we identified a previously unreported ERα-mediated effect of E2 on the inflammatory machinery. The study showed that the activation of the intracellular estrogen receptor shortens the LPS-induced pro-inflammatory phase and, by influencing the intrinsic and extrinsic programs, triggers the resolution of inflammation in RAW 264.7 cells. Through the regulation of the SOCS3 and STAT3 signaling pathways, E2 facilitates the progression of the inflammatory process toward the IL10-dependent acquired deactivation phenotype, which is responsible for tissue remodeling and the restoration of homeostatic conditions. The present study may provide an explanation for increased susceptibility to chronic inflammatory diseases in women after menopause, and it suggests novel anti-inflammatory treatments for such disorders.

Estrogen accelerates the resolution of inflammation in macrophagic cells / A. Villa, N. Rizzi, E. Vegeto, P. Ciana, A. Maggi. - In: SCIENTIFIC REPORTS. - ISSN 2045-2322. - 5(2015 Oct 19). [10.1038/srep15224]

Estrogen accelerates the resolution of inflammation in macrophagic cells

A. Villa
;
N. Rizzi
Secondo
;
E. Vegeto;P. Ciana
Penultimo
;
A. Maggi
Ultimo
2015

Abstract

Although 17β-estradiol (E2) anti-inflammatory activity has been well described, very little is known about the effects of this hormone on the resolution phase of the inflammatory process. Here, we identified a previously unreported ERα-mediated effect of E2 on the inflammatory machinery. The study showed that the activation of the intracellular estrogen receptor shortens the LPS-induced pro-inflammatory phase and, by influencing the intrinsic and extrinsic programs, triggers the resolution of inflammation in RAW 264.7 cells. Through the regulation of the SOCS3 and STAT3 signaling pathways, E2 facilitates the progression of the inflammatory process toward the IL10-dependent acquired deactivation phenotype, which is responsible for tissue remodeling and the restoration of homeostatic conditions. The present study may provide an explanation for increased susceptibility to chronic inflammatory diseases in women after menopause, and it suggests novel anti-inflammatory treatments for such disorders.
Multidisciplinary
Settore BIO/14 - Farmacologia
   Imaging of Neuroinflammation in Neurodegenerative Diseases
   INMIND
   EUROPEAN COMMISSION
   FP7
   278850
19-ott-2015
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/345302
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