Multiple sclerosis (MS) is an autoimmune, demyelinating disorder of unknown etiology, in which viruses have been suggested as etiological/triggering agents. The attention to the association between viruses and MS has been rekindled by the development of progressive multifocal leukoencephalopathy in natalizumab-treated MS patients. Here we report the case of a woman with JC virus (JCV) replication in the cerebrospinal fluid, blood and urine collected at the first symptoms of MS and during several follow-up visits. This observation shows that JCV can be associated with MS without a relation with natalizumab treatment, although the triggering role of JCV in some cases of MS will require further studies.
JC Virus Replication at the First Symptoms of Multiple Sclerosis : a Case Report / S. Delbue, C.S. Tadeo, F. Elia, P. Ferrante. - In: INTERVIROLOGY. - ISSN 0300-5526. - 58:5(2016 Feb), pp. 278-282. [10.1159/000441473]
JC Virus Replication at the First Symptoms of Multiple Sclerosis : a Case Report
S. DelbuePrimo
;F. EliaPenultimo
;P. FerranteUltimo
2016
Abstract
Multiple sclerosis (MS) is an autoimmune, demyelinating disorder of unknown etiology, in which viruses have been suggested as etiological/triggering agents. The attention to the association between viruses and MS has been rekindled by the development of progressive multifocal leukoencephalopathy in natalizumab-treated MS patients. Here we report the case of a woman with JC virus (JCV) replication in the cerebrospinal fluid, blood and urine collected at the first symptoms of MS and during several follow-up visits. This observation shows that JCV can be associated with MS without a relation with natalizumab treatment, although the triggering role of JCV in some cases of MS will require further studies.Pubblicazioni consigliate
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