Natalizumab is a humanized monoclonal antibody against the α4 subunit of VLA-4 integrin that is used to treat conditions such as multiple sclerosis (MS). Although its effects on lymphocytes have been widely described, little is known about its effects on monocytes. Here we described the effects of natalizumab treatment on peripheral blood monocytes from a small cohort of MS patients in terms of relative frequencies and surface integrin (CD49d and CD18) expression. We showed that natalizumab treatment altered the surface integrin expression on monocyte subsets in the peripheral compartment, suggesting a role for them as mediators of natalizumab effects.

Upregulation of integrin expression on monocytes in multiple sclerosis patients treated with natalizumab / S. Dallari, D. Franciotta, S. Carluccio, L. Signorini, M. Gastaldi, E. Colombo, R. Bergamaschi, F. Elia, S. Villani, P. Ferrante, S. Delbue. - In: JOURNAL OF NEUROIMMUNOLOGY. - ISSN 0165-5728. - 287(2015 Oct 15), pp. 76-79. [10.1016/j.jneuroim.2015.08.010]

Upregulation of integrin expression on monocytes in multiple sclerosis patients treated with natalizumab

S. Dallari;S. Carluccio;L. Signorini;F. Elia;S. Villani;P. Ferrante;S. Delbue
2015

Abstract

Natalizumab is a humanized monoclonal antibody against the α4 subunit of VLA-4 integrin that is used to treat conditions such as multiple sclerosis (MS). Although its effects on lymphocytes have been widely described, little is known about its effects on monocytes. Here we described the effects of natalizumab treatment on peripheral blood monocytes from a small cohort of MS patients in terms of relative frequencies and surface integrin (CD49d and CD18) expression. We showed that natalizumab treatment altered the surface integrin expression on monocyte subsets in the peripheral compartment, suggesting a role for them as mediators of natalizumab effects.
Monocytes; Multiple sclerosis; Natalizumab
Settore MED/07 - Microbiologia e Microbiologia Clinica
15-ott-2015
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/345081
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