As previously showed for the classical self renewing tissues (i.e. bone marrow, gut and skin), rapidly changing concepts about tissue stem cell biology identify the liver as a maturational lineage system capable to generate mature cells (hepatocytes and cholangiocytes) from a resident stem cells compartment localized near the so called Canals of Hering. At present liver transplantation is the only available therapy for end stage liver diseases and there is an ever increasing shortage of donor livers. Thus in the last decades, HPC has becoming the object of many researchers since HPC might offer a new therapeutic approach for controlling the evolution of chronic liver diseases. The aim of the present review is to update readers with the evolving concepts about hepatic stem cells biology, their characterization and isolation methods and finally their therapeutic potential.

Histologic analysis of human alveolar bone regenerated with xenograft and rh-platelet-derived growth factor-BB / C.P.B. Dellavia, F. Orlando, A. Colombo, F. Bonomi, R. Micheletti. - In: ITALIAN JOURNAL OF ANATOMY AND EMBRYOLOGY. - ISSN 1122-6714. - 112:s2(2007), pp. 93-93. ((Intervento presentato al 61. convegno Convegno della Società Italiana di Anatomia ed Istologia tenutosi a Sassari nel 2007.

Histologic analysis of human alveolar bone regenerated with xenograft and rh-platelet-derived growth factor-BB

C.P.B. Dellavia;F. Orlando;
2007

Abstract

As previously showed for the classical self renewing tissues (i.e. bone marrow, gut and skin), rapidly changing concepts about tissue stem cell biology identify the liver as a maturational lineage system capable to generate mature cells (hepatocytes and cholangiocytes) from a resident stem cells compartment localized near the so called Canals of Hering. At present liver transplantation is the only available therapy for end stage liver diseases and there is an ever increasing shortage of donor livers. Thus in the last decades, HPC has becoming the object of many researchers since HPC might offer a new therapeutic approach for controlling the evolution of chronic liver diseases. The aim of the present review is to update readers with the evolving concepts about hepatic stem cells biology, their characterization and isolation methods and finally their therapeutic potential.
Cholangiocytes; Hepatic progenitor cells; Hepatic stem cells; Liver regeneration
Settore BIO/16 - Anatomia Umana
Società Italiana di Anatomia e Istologia
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/34346
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