Although effective and safe, carotid endarterectomy (CEA) implies a reduced blood flow to the brain and likely an ischemia/reperfusion event. The high rate of uneventful outcomes associated with CEA suggests the activation of brain endogenous protection mechanisms aimed at limiting the possible ischemia/reperfusion damage. This study aims at assessing whether CEA triggers protective mechanismssuch as brain release of erythropoietin and nitric oxide. CEA was performed in 12 patients; blood samples were withdrawn simultaneously from the surgically exposed ipsilateral jugular and leg veins before, during (2 and 40 min) and after clamp removal (2 min). Plasma antioxidant capacity, carbonylated proteins, erythropoietin, nitrates and nitrites (NOx) were determined. No changes in intraoperative EEG, peripheral and transcranial blood oxygen saturation were detectable, and no patients showed any neurologic sign after the intervention. Antioxidant capacity and protein carbonylation in plasma were unaffected. Differently, erythropoietin, VEGF, TNF-α and NOx increased during clamping in the jugular blood (2 and 40 min), while no changes were observed in the peripheral circulation. These results show that blood erythropoietin, VEGF, TNF-α, and NOx increased in the brain during uncomplicated CEA. This may represent an endogenous self-activated neuroprotective mechanism aimed at the prevention of ischemia/reperfusion damage.
Enhanced brain release of erythropoietin, cytokines and NO during carotid clamping / S. Carelli, G. Ghilardi, P. Bianciardi, E. Latorre, F. Rubino, M. Bissi, A.M. Di Giulio, M. Samaja, A. Gorio. - In: NEUROLOGICAL SCIENCES. - ISSN 1590-1874. - 37:2(2016 Feb 01), pp. 243-252.
|Titolo:||Enhanced brain release of erythropoietin, cytokines and NO during carotid clamping|
GHILARDI, GIORGIO (Secondo)
SAMAJA, MICHELE (Penultimo)
GORIO, ALFREDO (Ultimo)
|Parole Chiave:||Carotid endarterectomy; Erythropoietin; Neuroprotection; Nitric oxide; Neurology (clinical); Psychiatry and Mental Health;|
|Settore Scientifico Disciplinare:||Settore BIO/14 - Farmacologia|
Settore BIO/10 - Biochimica
|Data di pubblicazione:||1-feb-2016|
|Data ahead of print / Data di stampa:||2015|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1007/s10072-015-2398-4|
|Appare nelle tipologie:||01 - Articolo su periodico|