Timely diagnosis of pneumonia in intubated critically ill patients is rather challenging. Pentraxin 3 (PTX3) is an acute-phase mediator produced by various cell types in the lungs. Animal studies have shown that, during pneumonia, PTX3 participates in fine-tuning of inflammation (for example, microbial clearance and recruitment of neutrophils). We previously described an association between alveolar PTX3 and lung infection in a small group of intubated patients. The aim of the present study was to determine a threshold level of alveolar PTX3 with elevated sensitivity and specificity for microbiologically confirmed pneumonia.
Alveolar pentraxin 3 as an early marker of microbiologically confirmed pneumonia : a threshold-finding prospective observational study / T. Mauri, A. Coppadoro, M. Bombino, G. Bellani, V. Zambelli, C. Fornari, L. Berra, E.A. Bittner, U. Schmidt, M. Sironi, B. Bottazzi, P. Brambilla, A. Mantovani, A. Pesenti. - In: CRITICAL CARE. - ISSN 1364-8535. - 18:5(2014), pp. 562.1-562.10.
|Titolo:||Alveolar pentraxin 3 as an early marker of microbiologically confirmed pneumonia : a threshold-finding prospective observational study|
|Parole Chiave:||Adult; Aged; Biological Markers; Bronchoalveolar Lavage Fluid; C-Reactive Protein; Calcitonin; Diagnosis, Differential; Female; Humans; Intensive Care Units; Male; Middle Aged; Pneumonia, Bacterial; Pneumonia, Viral; Prospective Studies; Protein Precursors; ROC Curve; Respiration, Artificial; Sensitivity and Specificity; Serum Amyloid P-Component|
|Settore Scientifico Disciplinare:||Settore MED/41 - Anestesiologia|
|Data di pubblicazione:||2014|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1186/s13054-014-0562-5|
|Appare nelle tipologie:||01 - Articolo su periodico|