Autoantibodies to double-stranded DNA (dsDNA) are, by definition, serological markers of systemic lupus erythematosus. However, the clinical value of anti-dsDNA antibodies largely depends on the assay principle and analytical variables of the methods used to quantitate and immunologically characterize them. In the present article, an overview of current methods for anti-dsDNA antibody detection is presented, together with a look at the future trends in technologies newly employed in this field.

Evaluation of current methods for the measurement of serum anti double-stranded DNA antibodies / A. Ghirardello, D. Villalta, G. Morozzi, A. Afeltra, M. Galeazzi, R. Gerli, A. Mathieu, P.L. Meroni, P. Migliorini, A. Radice, V. Riccieri, A. Ruffatti, G.D. Sebastiani, A. Tincani, A. Doria, FIRMA group. - In: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. - ISSN 0077-8923. - 1109:(2007), pp. 401-406. [10.1196/annals.1398.045]

Evaluation of current methods for the measurement of serum anti double-stranded DNA antibodies

P.L. Meroni;
2007

Abstract

Autoantibodies to double-stranded DNA (dsDNA) are, by definition, serological markers of systemic lupus erythematosus. However, the clinical value of anti-dsDNA antibodies largely depends on the assay principle and analytical variables of the methods used to quantitate and immunologically characterize them. In the present article, an overview of current methods for anti-dsDNA antibody detection is presented, together with a look at the future trends in technologies newly employed in this field.
Anti-double-stranded DNA antibody; Diagnostic accuracy; Laboratory methods; Systemic lupus erythematosus
Settore MED/16 - Reumatologia
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/33746
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