Intervening in the renin-angiotensin-system (RAS) early in the course of diabetic kidney disease (DKD) may be more beneficial in delaying end-stage-renal-disease (ESRD) than late intervention. However, prospective randomized controlled trial data are lacking. We developed and validated a model to simulate progression of DKD from early onset until ESRD, and assessed the effect of RAS intervention in early, intermediate and advanced stages of DKD.
Early renin-angiotensin-system intervention is more beneficial than late intervention in delaying end-stage renal disease in patients with type 2 diabetes / B. Schievink, T. Kröpelin, S. Mulder, H. Parving, G. Remuzzi, J. Dwyer, P. Vemer, D. de Zeeuw, H.L. Heerspink. - In: DIABETES, OBESITY AND METABOLISM. - ISSN 1462-8902. - 18:1(2016 Jan), pp. 64-71. [10.1111/dom.12583]
Early renin-angiotensin-system intervention is more beneficial than late intervention in delaying end-stage renal disease in patients with type 2 diabetes
G. Remuzzi;
2016
Abstract
Intervening in the renin-angiotensin-system (RAS) early in the course of diabetic kidney disease (DKD) may be more beneficial in delaying end-stage-renal-disease (ESRD) than late intervention. However, prospective randomized controlled trial data are lacking. We developed and validated a model to simulate progression of DKD from early onset until ESRD, and assessed the effect of RAS intervention in early, intermediate and advanced stages of DKD.
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