Knowledge of the distribution spectrum of causative organisms and their resistance patterns has become a core requirement for the rational and effective management of urinary tract infections. In the context of a prospective trial on the use of antibiotic prophylaxis in infants with underling kidney malformations, we conducted an online survey among paediatric nephrologists on positive urine cultures (July 2010-June 2012) from both hospitalized and non-hospitalized infants under 24 months of age. We collected 4745 urine cultures (UCs) at 18 units in 10 European countries. Escherichia coli was the most frequent bacterium isolated from UCs; however, in 10/16 hospitals and in 6/15 community settings, E. coli was isolated in less than 50% of the total positive UCs. Other bacterial strains were Klebsiella, Enterococcus, Proteus and Pseudomonas not only from hospital settings. E. coli showed a high resistance to amoxicillin and trimethoprim and variable to cephalosporin. Nitrofurantoin had a good rate of efficacy, with 11/16 hospitals and 11/14 community settings reporting a resistance lower than 5%. CONCLUSION: E. coli is the most common organism causing UTIs in infants; however, other bacterial strains are frequently isolated. As a result, antibiotic prophylaxis should be more elastic and adaptable over time in order to guarantee maximum efficacy.
Pathogens causing urinary tract infections in infants : a European overview by the ESCAPE study group / I. Alberici, A.K. Bayazit AK, D. Drozdz, S. Emre, M. Fischbach, J. Harambat, A. Jankauskiene, M. Litwin, S. Mir, W. Morello, A. Peco-Antic, P. Sallay, L. Sever, G.D. Simonetti, P. Szczesniak, A. Teixeira, E. Vidal, E. Wuehl, O. Mehls, L.T. Weber, F. Schaefer, G. Montini, ESCAPE Study Group, PREDICT Trial. - In: EUROPEAN JOURNAL OF PEDIATRICS. - ISSN 0340-6199. - 174:6(2015 Jun), pp. 783-790.
|Titolo:||Pathogens causing urinary tract infections in infants : a European overview by the ESCAPE study group|
|Parole Chiave:||Urinary tract infection; Antibiotic resistance; Infants; Escherichia coli; Urine culture|
|Settore Scientifico Disciplinare:||Settore MED/38 - Pediatria Generale e Specialistica|
|Data di pubblicazione:||giu-2015|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1007/s00431-014-2459-3|
|Appare nelle tipologie:||01 - Articolo su periodico|