Idiopathic nephrotic syndrome represents the most common type of primary glomerular disease in children: glucocorticoids (GCs) are the first-line therapy, even if considerable interindividual differences in thepir efficacy and side effects have been reported. Immunosuppressive and anti-inflammatory effects of these drugs are mainly due to the GC-mediated transcription regulation of pro- and anti-inflammatory genes. This mechanism of action is the result of a complex multistep pathway that involves the glucocorticoid receptor and several other proteins, encoded by polymorphic genes. Aim of this review is to highlight the current knowledge on genetic variants that could affect GC response, particularly focusing on children with idiopathic nephrotic syndrome.

Glucocorticoid pharmacogenetics in pediatric idiopathic nephrotic syndrome / E. Cuzzoni, S. De Iudicibus, R. Franca, G. Stocco, M. Lucafò, M. Pelin, D. Favretto, A. Pasini, G. Montini, G. Decorti. - In: PHARMACOGENOMICS. - ISSN 1462-2416. - 16:14(2015 Sep), pp. 1631-1648. [10.2217/pgs.15.101]

Glucocorticoid pharmacogenetics in pediatric idiopathic nephrotic syndrome

G. Montini
Penultimo
;
2015

Abstract

Idiopathic nephrotic syndrome represents the most common type of primary glomerular disease in children: glucocorticoids (GCs) are the first-line therapy, even if considerable interindividual differences in thepir efficacy and side effects have been reported. Immunosuppressive and anti-inflammatory effects of these drugs are mainly due to the GC-mediated transcription regulation of pro- and anti-inflammatory genes. This mechanism of action is the result of a complex multistep pathway that involves the glucocorticoid receptor and several other proteins, encoded by polymorphic genes. Aim of this review is to highlight the current knowledge on genetic variants that could affect GC response, particularly focusing on children with idiopathic nephrotic syndrome.
P-gp; glucocorticoid receptor; glucocorticoid receptor heterocomplex; glucocorticoids; idiopathic nephrotic syndrome; inflammatory mediators; polymorphisms
Settore MED/38 - Pediatria Generale e Specialistica
set-2015
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/335248
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