PURPOSE: To compare phenotype features and survival of triple-negative breast cancers (TNBC) versus non-TNBCs detected during a multimodal annual screening of high-risk women. EXPERIMENTAL DESIGN: Analysis of data from asymptomatic high-risk women diagnosed with invasive breast cancer during the HIBCRIT-1 study with median 9.7-year follow-up. RESULTS: Of 501 enrolled women with BRCA1/2 mutation or strong family history (SFH), 44 were diagnosed with invasive breast cancers: 20 BRCA1 (45%), 9 BRCA2 (21%), 15 SFH (34%). Magnetic resonance imaging (MRI) sensitivity (90%) outperformed that of mammography (43%, P < 0.001) and ultrasonography (61%, P = 0.004). The 44 cases (41 screen-detected; 3 BRCA1-associated interval TNBCs) comprised 14 TNBCs (32%) and 30 non-TNBCs (68%), without significant differences for age at diagnosis, menopausal status, prophylactic oophorectomy, or previous breast cancer. Of 14 TNBC patients, 11 (79%) were BRCA1; of the 20 BRCA1 patients, 11 (55%) had TNBC; and of 15 SFH patients, 14 (93%) had non-TNBCs (P = 0.007). Invasive ductal carcinomas (IDC) were 86% for TNBCs versus 43% for non-TNBCs (P = 0.010), G3 IDCs 71% versus 23% (P = 0.006), size 16 ± 5 mm versus 12 ± 6 mm (P = 0.007). TNBC patients had more frequent ipsilateral mastectomy (79% vs. 43% for non-TNBCs, P = 0.050), contralateral prophylactic mastectomy (43% vs. 10%, P = 0.019), and adjuvant chemotherapy (100% vs. 44%, P < 0.001). The 5-year overall survival was 86% ± 9% for TNBCs versus 93% ± 5% (P = 0.946) for non-TNBCs; 5-year disease-free survival was 77% ± 12% versus 76% ± 8% (P = 0.216). CONCLUSIONS: In high-risk women, by combining an MRI-including annual screening with adequate treatment, the usual reported gap in outcome between TNBCs and non-TNBCs could be reduced. .
Triple negative versus non-triple negative breast cancers in high-risk women : phenotype features and survival from the HIBCRIT-1 MRI-including screening study / F. Podo, F. Santoro, G. Di Leo, S. Manoukian, C. De Giacomi, S. Corcione, L. Cortesi, L.A. Carbonaro, R.M. Trimboli, A. Cilotti, L. Preda, B. Bonanni, M. Pensabene, L. Martincich, A. Savarese, A. Contegiacomo, F. Sardanelli. - In: CLINICAL CANCER RESEARCH. - ISSN 1078-0432. - 22:4(2016 Feb 15), pp. 895-904.
|Titolo:||Triple negative versus non-triple negative breast cancers in high-risk women : phenotype features and survival from the HIBCRIT-1 MRI-including screening study|
SARDANELLI, FRANCESCO (Ultimo)
|Settore Scientifico Disciplinare:||Settore MED/36 - Diagnostica per Immagini e Radioterapia|
|Data di pubblicazione:||15-feb-2016|
|Data ahead of print / Data di stampa:||26-ott-2015|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1158/1078-0432.CCR-15-0459|
|Appare nelle tipologie:||01 - Articolo su periodico|