This review summarizes the current understanding of the role of sphingolipid biosynthesis in the pathobiology of cryptococcosis, focusing on the production and functions of the antigenic glycosphingolipid (GSL) glucosylceramide (GlcCer) and its role in the host-pathogen interaction. In addition, the presence of GlcCer and structurally similar molecules present in other pathogens will be discussed and highlighted for their importance as potential therapeutic targets.

Biosynthesis and immunogenicity of glucosylceramide in Cryptococcus neoformans and other human pathogens / R. Rhome, T. Mcquiston, T. Kechichian, A. Bielawska, M. Hennig, M. Drago, G. Morace, C. Luberto, M. Del Poeta. - In: EUKARYOTIC CELL. - ISSN 1535-9778. - 6:10(2007 Oct), pp. 1715-1726.

Biosynthesis and immunogenicity of glucosylceramide in Cryptococcus neoformans and other human pathogens

M. Drago;G. Morace;
2007-10

Abstract

This review summarizes the current understanding of the role of sphingolipid biosynthesis in the pathobiology of cryptococcosis, focusing on the production and functions of the antigenic glycosphingolipid (GSL) glucosylceramide (GlcCer) and its role in the host-pathogen interaction. In addition, the presence of GlcCer and structurally similar molecules present in other pathogens will be discussed and highlighted for their importance as potential therapeutic targets.
Settore MED/07 - Microbiologia e Microbiologia Clinica
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/33449
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