Infection with Ebola virus (EBOV) results in a life-threatening disease, with reported mortality rates between 50%-70%. The factors that determine patient survival are poorly understood; however, clinical observations indicate that EBOV viremia may be associated with fatal outcome. We conducted a study of the kinetics of Zaire EBOV viremia in patients with EBOV disease (EVD) who were managed at an Ebola Treatment Centre in Sierra Leone during the recent West African outbreak.
Blood kinetics of Ebola virus in survivors and nonsurvivors / S. Lanini, G. Portella, F. Vairo, G.P. Kobinger, A. Pesenti, M. Langer, S. Kabia, G. Brogiato, J. Amone, C. Castilletti, R. Miccio, A. Zumla, M.R. Capobianchi, A. Di Caro, G. Strada, G. Ippolito, I. EMERGENCY EBOV Sierra Leone Study group. - In: THE JOURNAL OF CLINICAL INVESTIGATION. - ISSN 0021-9738. - 125:12(2015 Dec), pp. 4692-4698. [10.1172/JCI83111]
Blood kinetics of Ebola virus in survivors and nonsurvivors
A. Pesenti;M. Langer;
2015
Abstract
Infection with Ebola virus (EBOV) results in a life-threatening disease, with reported mortality rates between 50%-70%. The factors that determine patient survival are poorly understood; however, clinical observations indicate that EBOV viremia may be associated with fatal outcome. We conducted a study of the kinetics of Zaire EBOV viremia in patients with EBOV disease (EVD) who were managed at an Ebola Treatment Centre in Sierra Leone during the recent West African outbreak.
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