AIM : This study investigates the effects of surgery on collagen turnover in patients affected by Crohn's disease (CD). METHODS : Fifteen patients affected by active CD, assessed according to the Crohn's disease activity index, and confirmed by histology, with different pharmacological treatments, were enrolled in the study. N-Terminal propeptide of type III collagen was assessed on peripheral blood before and 6 months after surgery, as an index of collagen turnover. A control group of 15 healthy age- and sex-matched subjects was also studied. RESULTS : In CD patients peripheral N-terminal propeptide of type III collagen serum levels were significantly higher than in controls before surgery (5.0 +/- 1.8 vs 2.7 +/- 0.7 mug/l, respectively; p = 0.0001). Six months after these values were significantly reduced (from 5.0 +/- 1.8 to 3.1 +/- 0.8 mug/l; p = 0.003). Independently on the pretreatment regimen and the duration of the disease, an improvement in the patients' symptoms was observed. CONCLUSIONS : The surgical resection of the affected intestinal segment in CD patients seems to be able to break down the collagen synthesis processes. Peripheral N-terminal propeptide of type III collagen could be seen as an additive marker to clinical and endoscopic observations after surgery.
Effects of surgery on peripheral N-terminal propeptide of type III procollagen in patients with Crohn’s disease / M. De Simone, M.M. Ciulla, U. Cioffi, L. Poggi, B. Oreggia, R. Paliotti, F. Botti, A. Carrara, F. Agosti, A. Sartorio, E. Contessini-Avesani. - In: JOURNAL OF GASTROINTESTINAL SURGERY. - ISSN 1091-255X. - 11:10(2007 Oct), pp. 1361-1364.
|Titolo:||Effects of surgery on peripheral N-terminal propeptide of type III procollagen in patients with Crohn’s disease|
DE SIMONE, MATILDE (Primo)
CIULLA, MICHELE MARIO (Secondo)
CONTESSINI AVESANI, ETTORE (Ultimo)
|Parole Chiave:||Crohn's disease; Inflammatory bowel disease; Procollagen type III peptide|
|Settore Scientifico Disciplinare:||Settore MED/18 - Chirurgia Generale|
|Data di pubblicazione:||ott-2007|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1007/s11605-007-0233-9|
|Appare nelle tipologie:||01 - Articolo su periodico|