Feline immunodeficiency virus (FIV) infection causes a widespread natural immunodeficiency syndrome in cats that is considered a suitable animal model for studying human immunodeficiency virus (HIV) infection and pathogenesis, Short term cultures of bone marrow derived feline macrophages stimulated with recombinant feline interferon-gamma (r-IFN-gamma) and lipopolysaccharide (LPS) were shown to produce nitric oxide. Feline macrophages were shown to express cannabinoid receptors, and nitric oxide production decreased after in vitro exposure to synthetic cannabinoid CP-55940. Both cannabinoid receptors, CB1 and CB2, were involved in this process, since the inhibition was reversed by selective cannabinoid antagonists for both of these receptors.
Cannabinoids inhibit nitric oxide production in bone marrow derived feline macrophages / W. Ponti, T. Rubino, M. Bardotti, G. Poli, D. Parolaro. - In: VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY. - ISSN 0165-2427. - 82:3-4(2001), pp. 203-214.
|Titolo:||Cannabinoids inhibit nitric oxide production in bone marrow derived feline macrophages|
PONTI, WILMA (Primo)
POLI, GIORGIO (Penultimo)
|Parole Chiave:||cat ; macrophage cultures ; nitric oxide ; cannabinoids|
|Settore Scientifico Disciplinare:||Settore VET/05 - Malattie Infettive degli Animali Domestici|
|Data di pubblicazione:||2001|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/S0165-2427(01)00357-9|
|Appare nelle tipologie:||01 - Articolo su periodico|