Among transmissible spongiform encephalopathies (TSE), particularly dreadful are the bovine spongiform encephalopathy (BSE), because of its epidemic character, and the new variant of Creutzfeldt-Jakob disease (vCJD) in man, possibly related to BSE prion, through the intake of infected food. To treat TSE, many potentially therapeutic agents have been tested: some of them, among which is Congo Red (CAS 573-58-0, CR), delayed the onset of symptoms in scrapie-infected rodents, and some CR derivatives proved to be effective in vitro. The capacity of a synthesized CR derivative (CR-A) and of the aromatic central benzidine rings of CR (CR-B) to abrogate scrapie-induced disease in experimentally infected hamsters was assayed. CR, used as reference substance, administered i.e. after pre-incubatlon with the scrapie inoculum, was strongly effective in slowing the progression of the infection, while both CR-A and CR-B, administered alone or together, were not effective. Both CR-A and CR, when administered by subcutaneous route in i.e. scrapie-infected animals, prolonged the survival time in comparison to controls; CR-B was not effective. Moreover, both CR and CR-A were very effective in prolonging the survival time of i.p. scrapie-infected hamsters. The hypothesis of possible different mechanisms of interaction between CR or CR-A and the scrapie agent related to the chemical structures of the molecules is discussed.
|Titolo:||Evaluation of anti-prion activity of Congo Red and its derivatives in experimentally infected hamsters|
|Autori interni:||PONTI, WILMA (Ultimo)|
POLI, GIORGIO (Primo)
MARTINO, PIERA ANNA (Secondo)
DALL'ARA, PAOLA EMANUELA
BAREGGI, SILVIO RICCARDO CARLO
|Settore Scientifico Disciplinare:||Settore CHIM/08 - Chimica Farmaceutica|
Settore VET/05 - Malattie Infettive degli Animali Domestici
Settore BIO/14 - Farmacologia
|Data di pubblicazione:||2004|
|Appare nelle tipologie:||01 - Articolo su periodico|
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